System identification theory in pharmacokinetic modeling of dynamic contrast-enhanced MRI: influence of contrast injection

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Hugo J W L AertsWalter H Backes

Abstract

Optimization of experimental settings of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), like the contrast administration protocol, is of great importance for reliable quantification of the microcirculatory properties, such as the volume transfer-constant K(trans). Using system identification theory and computer simulations, the confounding effects of volume, rate and multiplicity of a contrast injection on the reliability of K(trans) estimation was assessed. A new tracer-distribution model (TDM), based on in vivo data from rectal cancer patients, served to describe the relationship between the contrast agent injection and the blood time-course. A pharmacokinetic model (PKM) was used to describe the relation between the blood and tumor tissue time-courses. By means of TDM and PKM in series, the tissue-transfer function of the PKM was analyzed. As both the TDM and PKM represented low-frequency-pass filters, the energy-density at low frequencies of the blood and tissue time-courses was larger than at high frequencies. The simulations, based on measurements in humans, predict that the K(trans) is most reliable with a high injection volume administered in a single injection, where high rates only modestly improve K(...Continue Reading

References

Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S Tofts, A G Kermode
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·P S Tofts
Dec 5, 1998·Magnetic Resonance Imaging·E HendersonT Y Lee
Dec 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K S St Lawrence, T Y Lee
Dec 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K S St Lawrence, T Y Lee
Oct 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·J L Evelhoch
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·J L EvelhochH M Swartz
Aug 19, 2000·Haemophilia : the Official Journal of the World Federation of Hemophilia·R Ljung
Feb 27, 2001·Computer Methods and Programs in Biomedicine·X LiK Wong
May 30, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R E PortG Brix
Nov 1, 2001·Topics in Magnetic Resonance Imaging : TMRI·M V KnoppP Choyke
Mar 1, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David L Buckley
Sep 28, 2002·Investigative Radiology·Lutz LudemannClaus Zimmer
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Anwar R Padhani
Oct 22, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A R Padhani
Jun 5, 2003·Nature Medicine·Donald M McDonald, Peter L Choyke
Sep 25, 2004·Journal of Magnetic Resonance Imaging : JMRI·Mark A Horsfield, Bruno Morgan
Aug 30, 2005·International Journal of Radiation Oncology, Biology, Physics·Quido G de LussanetRegina G H Beets-Tan
Jul 22, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Caleb RobertsGeoff J M Parker
Jan 11, 2007·British Journal of Cancer·J P B O'ConnorG C Jayson
Jan 11, 2007·Radiology·Phillip H KuoShawn E Cowper
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Richard G P LopataNatal A W van Riel

❮ Previous
Next ❯

Citations

Jul 28, 2010·Investigative Radiology·Sabine HeilandMartin Krix
Jan 19, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marco H M JanssenGuido Lammering
Sep 8, 2009·International Journal of Radiation Oncology, Biology, Physics·Roel G J KierkelsHugo J W L Aerts
Jul 23, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karolien JaspersWalter H Backes
Sep 25, 2012·Journal of Magnetic Resonance Imaging : JMRI·Jan SedlacikClaudia M Hillenbrand
Feb 27, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marieke HeisenBart M ter Haar Romeny
Jun 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Matthias C SchabelLeigh A Neumayer
Jul 24, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tammo RukatStefan A Reinsberg
Sep 3, 2014·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Guillaume TartareNacim Betrouni
Apr 27, 2016·Current Atherosclerosis Reports·Raf H M van HoofM Eline Kooi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Richard G P LopataNatal A W van Riel
International Journal of Radiation Oncology, Biology, Physics
Quido G de LussanetRegina G H Beets-Tan
Vascular Health and Risk Management
Mathias Goyen
© 2022 Meta ULC. All rights reserved