DOI: 1206.0094Apr 25, 2014Paper

System level mechanisms of adaptation, learning, memory formation and evolvability: the role of chaperone and other networks

David M GyurkoPeter Csermely


During the last decade, network approaches became a powerful tool to describe protein structure and dynamics. Here, we describe first the protein structure networks of molecular chaperones, then characterize chaperone containing sub-networks of interactomes called as chaperone-networks or chaperomes. We review the role of molecular chaperones in short-term adaptation of cellular networks in response to stress, and in long-term adaptation discussing their putative functions in the regulation of evolvability. We provide a general overview of possible network mechanisms of adaptation, learning and memory formation. We propose that changes of network rigidity play a key role in learning and memory formation processes. Flexible network topology provides "learning competent" state. Here, networks may have much less modular boundaries than locally rigid, highly modular networks, where the learnt information has already been consolidated in a memory formation process. Since modular boundaries are efficient filters of information, in the "learning competent" state information filtering may be much smaller, than after memory formation. This mechanism restricts high information transfer to the "learning competent" state. After memory fo...Continue Reading

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