Systematic analysis of the p53-related microRNAs in breast cancer revealing their essential roles in the cell cycle

Oncology Letters
Enxiang ZhouJianlin Zhou

Abstract

Numerous miRNAs have been found to be involved in the regulation of the p53 signaling pathway. Conversely, p53 regulates the transcription or processing of microRNAs (miRNAs). Given that complexities in the association between p53 and miRNAs exist, and due to the rapidly increasing amount of literature regarding the interactions between p53 and miRNAs, the present study systematically analyzed the associations between miRNAs and p53 in breast cancer using a literature-based discovery approach, natural language processing. A total of 22 miRNAs were found to be associated with p53. Next, three popular online tools (PicTar, miRanda and TargetScan) were used to predict the targets of each miRNA, and certain targets were validated by experiments. Gene Ontology annotation and network analysis demonstrated that the majority of the targets of the p53-related miRNAs were enriched in the cell cycle process. These results suggest that, in addition to regulating the transcription of cell cycle-related genes, p53 also indirectly modulates the cell cycle via miRNAs.

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Citations

Oct 18, 2016·Frontiers in Genetics·Shivani SharmaRitu Kulshreshtha
Sep 22, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Farheen AlamWael M Abdel-Rahman
Jul 27, 2021·Journal of Oncology·Wei YanJian Zhang
May 12, 2018·Molecular Pharmaceutics·Saurabh SharmaDeepak Chitkara

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Methods Mentioned

BETA
two-hybrid
transfection

Software Mentioned

miRanda
PicTar
Medusa
R
NLP
TargetScan
KEGGSOAP
GSEABase
GenMAPP
Biomedical Named Entity Recognizer

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