Systematic and standardized comparison of reported amyloid-β receptors for sufficiency, affinity, and Alzheimer's disease relevance.

The Journal of Biological Chemistry
Levi M SmithStephen M Strittmatter

Abstract

Oligomeric assemblies of amyloid-β (Aβ) peptide (Aβo) in the brains of individuals with Alzheimer's disease (AD) are toxic to neuronal synapses. More than a dozen Aβ receptor candidates have been suggested to be responsible for various aspects of the molecular pathology and memory impairment in mouse models of AD. A lack of consistent experimental design among previous studies of different receptor candidates limits evaluation of the relative roles of these candidates, producing some controversy within the field. Here, using cell-based assays with several Aβ species, including Aβo from AD brains obtained by autopsy, we directly compared the Aβ-binding capacity of multiple receptor candidates while accounting for variation in expression and confirming cell surface expression. In a survey of 15 reported Aβ receptors, only cellular prion protein (PrPC), Nogo receptor 1 (NgR1), and leukocyte immunoglobulin-like receptor subfamily B member 2 (LilrB2) exhibited direct binding to synaptotoxic assemblies of synthetic Aβ. Both PrPC and NgR1 preferentially bound synaptotoxic oligomers rather than nontoxic monomers, and the method of oligomer preparation did not significantly alter our binding results. Hippocampal neurons lacking both NgR...Continue Reading

References

May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P LambertW L Klein
Apr 10, 1999·Nature Neuroscience·T TakahashiS M Strittmatter
May 22, 2002·Nature Immunology·Azusa UjikeToshiyuki Takai
Aug 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yuesong GongWilliam L Klein
Nov 5, 2003·Biochemistry·Brett A ChromyWilliam L Klein
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pascale N LacorWilliam L Klein
Dec 21, 2004·Nature Neuroscience·James P ClearyKaren H Ashe
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Olav M AndersenThomas E Willnow
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert SpoelgenBradley T Hyman
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James H ParkStephen M Strittmatter
Mar 17, 2006·Nature·Sylvain LesnéKaren H Ashe
Feb 3, 2007·BioTechniques·Michael R LamprechtAnne E Carpenter
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ganesh M ShankarBernardo L Sabatini
Feb 1, 2008·The Journal of Biological Chemistry·Margaret H MagdesianSérgio T Ferreira
Nov 30, 2010·Nature·Moustapha CisséLennart Mucke
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Jan 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne-Sophie CarloThomas E Willnow
Aug 8, 2013·The Journal of Clinical Investigation·Tae-In KamYong-Keun Jung
Sep 21, 2013·Science·Iryna Benilova, Bart De Strooper
Apr 4, 2014·Neurology·Douglas GalaskoUNKNOWN Alzheimer's Disease Cooperative Study
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Amy K Y FuNancy Y Ip
Dec 13, 2016·Cold Spring Harbor Perspectives in Medicine·Levi M Smith, Stephen M Strittmatter
Jan 15, 2018·Biological Psychiatry·Silvia A PurroJohn Collinge

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Citations

Aug 24, 2019·Journal of Neurotrauma·Edward J GoetzlKristine Yaffe
Mar 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erin L AbnerEdward J Goetzl
Aug 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Edward J Goetzl
Mar 4, 2020·Nature Reviews. Neurology·Jacob I Ayers, Stanley B Prusiner
Jul 16, 2019·Journal of Alzheimer's Disease : JAD·Rebecca Parodi-RullánSilvia Fossati
Apr 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Botond PenkeFerenc Bogár
Mar 16, 2021·Frontiers in Aging Neuroscience·Allal BoutajangoutThomas Wisniewski
Apr 10, 2021·Acta Neuropathologica Communications·Ivan Martinez-ValbuenaMaría-Rosario Luquin
May 1, 2021·Antibody Therapeutics·Mi DengCheng Cheng Zhang
Sep 18, 2021·ACS Medicinal Chemistry Letters·Gilbert M RishtonSusan M Catalano
Sep 14, 2021·Annual Review of Pharmacology and Toxicology·Khaled S Abd-Elrahman, Stephen S G Ferguson

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