Systematic assessment of the prognostic impact of membranous CD44v6 protein expression in colorectal cancer

Histopathology
Inti ZlobecAlessandro Lugli

Abstract

To assess systematically the membranous expression of CD44v6 in colorectal cancer by immunohistochemistry to determine its prognostic impact, the differential expression between primary and metastatic tumours and expression differences between the tumour centre and invasive front. Immunohistochemistry was performed for CD44v6 on two tissue microarrays. The first included 1279 colorectal tumours with full clinicopathological data. The second consisted of 50 matched primary and metastatic tumours sampled from the tumour centre and the invasive margin. A scoring system was tested by multiple observers. Receiver-operating characteristic curve analysis was used for cut-off point determination. Loss of membranous CD44v6 was associated with pT stage (P = 0.016; sensitivity 85.8%, specificity 20.1%), lymph node metastasis (P = 0.015; sensitivity 52.8%, specificity 55%), an infiltrating tumour margin (P < 0.001; sensitivity 71.4%, specificity 40%) and adverse prognosis (P = 0.011; hazard ratio 0.79, 95% confidence interval 0.7, 0.9), but was not an independent prognostic factor on multivariable analysis. Loss of expression occurred at the invasive front in both primary and metastatic lesions (P < 0.001). This study outlines an approach ...Continue Reading

References

Jun 6, 1987·Lancet·J R JassJ M Northover
Aug 7, 1996·Journal of the National Cancer Institute·T W JacobsS J Schnitt
Mar 7, 1998·Scandinavian Journal of Gastroenterology·V J WielengaS T Pals
Apr 21, 1998·Scandinavian Journal of Gastroenterology·K M RopponenV M Kosma
Jul 4, 1998·Human Pathology·D CoppolaH S Cooper
Dec 16, 1998·Virchows Archiv : an International Journal of Pathology·J D MuellerH Höfler
Apr 22, 1999·Diseases of the Colon and Rectum·R NeumayerR Schiessel
Feb 22, 2002·The Journal of Surgical Research·Klaus GüntherMarc A Reymond
May 23, 2002·International Journal of Colorectal Disease·M Morrin, P V Delaney
Jan 4, 2003·Nature Reviews. Molecular Cell Biology·Helmut PontaPeter A Herrlich
Sep 18, 2004·Virchows Archiv : an International Journal of Pathology·Martin KöbelSteffen Hauptmann
Jul 27, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Sep 17, 2005·Cell Death and Differentiation·A MielgoU Günthert
Jan 21, 2006·World Journal of Gastroenterology : WJG·Yong-Jun LiuJing-Fen Jia
Jul 5, 2006·Genes & Development·Chonghui ChengPhillip A Sharp
Oct 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gershon Y LockerUNKNOWN ASCO
Apr 20, 2007·Journal of Surgical Oncology·Chew Yee NganMorito Monden
Jun 21, 2007·Molecular Cancer Research : MCR·Sebastian KuhnMargot Zöller
Aug 4, 2007·Virchows Archiv : an International Journal of Pathology·Inti ZlobecAlessandro Lugli

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Citations

Sep 13, 2012·World Journal of Gastroenterology : WJG·Suvi Tuulia AvorantaJari Toivo Tapio Sundström
Jul 19, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L ChenX Su
Feb 1, 2014·Pathology Oncology Research : POR·Mi Jin Gu, Byung Ik Jang
Aug 10, 2013·Molecular Aspects of Medicine·S Di FrancoG Stassi
Mar 11, 2015·Proteomics. Clinical Applications·Lucy JankovaStephen J Clarke
Jan 10, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lin LvXiao-Hua Zhang
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Yao-Yao ZhangYan-Qing Ding
Mar 27, 2015·Journal of Cancer Research and Clinical Oncology·Jian-Wei XieChang-Ming Huang
Aug 25, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·H-G LiuH Shen
May 23, 2019·Frontiers in Oncology·Zhenpeng WangShaoqi Zong

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