Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease.

Food & Function
Tatjana RuskovskaDragan Milenkovic

Abstract

Flavanol intake positively influences several cardiometabolic risk factors in humans. However, the specific molecular mechanisms of action of flavanols, in terms of gene regulation, in the cell types relevant to cardiometabolic disease have never been systematically addressed. On this basis, we conducted a systematic literature review and a comprehensive bioinformatic analysis of genes whose expression is affected by flavanols in cells defining cardiometabolic health: hepatocytes, adipocytes, endothelial cells, smooth muscle cells and immune cells. A systematic literature search was performed using the following pre-defined criteria: treatment with pure compounds and metabolites (no extracts) at low concentrations that are close to their plasma concentrations. Differentially expressed genes were analyzed using bioinformatics tools to identify gene ontologies, networks, cellular pathways and interactions, as well as transcriptional and post-transcriptional regulators. The systematic literature search identified 54 differentially expressed genes at the mRNA level in in vitro models of cardiometabolic disease exposed to flavanols and their metabolites. Global bioinformatic analysis revealed that these genes are predominantly invol...Continue Reading

References

Aug 5, 2000·The Journal of Nutrition·A Scalbert, G Williamson
Dec 18, 2001·Experimental Biology and Medicine·F M Gregoire
Jun 24, 2004·The American Journal of Clinical Nutrition·Paul A KroonGary Williamson
Oct 12, 2005·International Journal of Cancer. Journal International Du Cancer·Shaun K RodriguezMohsen Meydani
Nov 2, 2005·Biochemical and Biophysical Research Communications·Karen Perez-de-ArceFederico Leighton
Jun 10, 2006·Gastroenterology·Silvio DaneseClaudio Fiocchi
Nov 15, 2006·Cellular and Molecular Life Sciences : CMLS·V C J de BoerJ Keijer
Mar 9, 2007·European Journal of Pharmacology·Marina Sánchez-HidalgoCatalina Alarcón de la Lastra
Apr 28, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·John H ChidlowChristopher G Kevil
Aug 19, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Michael Fenech
Sep 7, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gow-Chin YenTimothy Yu-Chi Fu
Feb 16, 2008·Archives of Biochemistry and Biophysics·Alejandra G ErlejmanPatricia I Oteiza
Mar 20, 2008·Archives of Biochemistry and Biophysics·Oliver SchnorrHelmut Sies
Nov 4, 2008·Molecular Nutrition & Food Research·Angélique StalmachAlan Crozier
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Mar 10, 2009·The Journal of Nutritional Biochemistry·Wing Pui Tsang, Tim Tak Kwok
May 16, 2009·Journal of Pharmaceutical and Biomedical Analysis·Montserrat DueñasCelestino Santos-Buelga
Dec 22, 2009·The Journal of Clinical Hypertension·Erik P Kirk, Samuel Klein
Mar 30, 2010·Basic & Clinical Pharmacology & Toxicology·Chen-Jing WangFang Guo
Apr 30, 2010·Database : the Journal of Biological Databases and Curation·V NeveuA Scalbert
Jun 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eui Hong ByunHirofumi Tachibana
Jan 14, 2011·Journal of Agricultural and Food Chemistry·Akiko YasudaJinichiro Koga
Feb 26, 2011·World Journal of Gastroenterology : WJG·Franco ScaldaferriRaimondo De Cristofaro
Apr 5, 2011·Current Atherosclerosis Reports·S Hani Najafi-Shoushtari
Jul 27, 2011·PloS One·Fran SupekTomislav Šmuc
Feb 15, 2012·Free Radical Biology & Medicine·Jingqi YanBaolu Zhao
Mar 20, 2012·Archives of Biochemistry and Biophysics·Marcela A Vazquez-PrietoPatricia I Oteiza
May 3, 2012·Annals of the New York Academy of Sciences·Pedro R MorenoK-Raman Purushothaman
Aug 16, 2012·Journal of Agricultural and Food Chemistry·Noemi González-AbuínAnna Ardévol

❮ Previous
Next ❯

Citations

Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pan ChenPeibo Li
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hanghang LouQihe Chen

❮ Previous
Next ❯

Software Mentioned

EndNote X6
GeneTrail2
Metascape
Revigo
BioCarta
Cytoscape
MetaCore
STRING
OmicsNet
MetaboAnalyst

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here