PMID: 7521093Sep 1, 1994Paper

Systematic biopsies accurately predict extracapsular extension of prostate cancer and persistent/recurrent detectable PSA after radical prostatectomy

Urology
V RaveryL Boccon-Gibod

Abstract

To determine if methodic analysis of systematic echo-guided biopsies associated with prostatic-specific antigen (PSA) and PSA density can accurately predict the actual pathologic stage of prostate cancer (Ca P). One hundred patients with clinically localized (T1, T2) Ca P who underwent radical prostatectomy (RP) were preoperatively staged by digital rectal examination (DRE), measurement of serum PSA (Yang Pros-check) and PSA density (PSAD), and transrectal echo-guided systematic biopsies (three in each lobe aiming to sample prostatic capsule) to evaluate T stage, Gleason grade, number of positive biopsies, and presence of cancer in the periprostatic tissues. Radical prostatectomy specimens were processed following the McNeal method. The PSA levels were measured every month for 2 years. Extracapsular disease was detected on the specimen in 45% of the patients, persistent/recurrent detectable PSA in 47% (mean follow-up 18 months). Clinical stage T2 B, presence of Gleason grade 4, PSA > 25 ng/mL, PSAD > 0.6, number of positive biopsies > 66% of the total number of cores taken had a positive predictive value (PPV), respectively, of 72%, 66%, 80%, and 87%. Periprostatic tissue was evaluable on the core biopsies in 77% of the cases. ...Continue Reading

Citations

Jul 15, 1996·Cancer·D J Grignon, W A Sakr
Jan 17, 1996·International Journal of Cancer. Journal International Du Cancer·F H ShröderB G Blijenberg
Jan 1, 1997·Virchows Archiv : an International Journal of Pathology·D G Bostwick, R Montironi
Sep 10, 2010·Virchows Archiv : an International Journal of Pathology·Ramzi RajabUNKNOWN Transatlantic Prostate Group
Dec 21, 2000·Current Oncology Reports·U Vaishampayan, M Hussain
Apr 27, 2007·Current Urology Reports·Gregory L LacyJavier Hernandez
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·G K ZagarsA C von Eschenbach
Jun 1, 1996·Urology·A E KatzR Buttyan
Apr 23, 2003·European Urology·Fernando J BiancoJ Edson Pontes
Mar 15, 1997·International Journal of Radiation Oncology, Biology, Physics·P A KupelianE A Klein
Jul 26, 2000·Journal of Endourology·M J CurranR A Roth
Sep 13, 2007·Journal of the National Cancer Institute·M Scott LuciaIan M Thompson
Jan 11, 2007·Journal of Clinical Pathology·P A Humphrey
Sep 11, 2002·American Journal of Clinical Pathology·James S LewisPeter A Humphrey
Mar 22, 2003·Lancet·Angelo M DeMarzoJonathan I Epstein
Jan 30, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·C A LawtonD A Kuban
May 27, 2009·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F MondetD Collomb
Dec 1, 2009·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F MondetD Collomb
Feb 6, 1999·International Urology and Nephrology·M CecchiL Fiorentini

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