Systematic classification and prediction of complications after nephrectomy in patients with metastatic renal cell carcinoma (RCC).

BJU International
Jonathan L SilbersteinPaul Russo

Abstract

Study Type - Harm (case series) Level of Evidence 4. What's known on the subject? and What does the study add? Radical nephrectomy for patients with metastatic renal cell carcinoma results in greater rates of morbidity than for those with less advanced disease. This study systematically characterizes complications associated with nephrectomy for metastatic RCC and identifies patient and disease characteristics that are associated with a greater risk of developing complications. Overall complications were relatively frequent, but major complications (grade 3 or greater) were rare. Increasing age and worsening performance status were associated with increased probability of complications. When complications were sustained, patients were less likely to receive systemic therapy in a timely fashion. These observations may influence the timing or patient selection for surgery or systemic therapy. • To evaluate and identify factors predictive for morbidity after radical nephrectomy in patients with metastatic renal cell carcinoma (mRCC). • We identified patients with mRCC who underwent nephrectomy at Memorial Sloan-Kettering Cancer Center (MSKCC) between 1989 and 2009. • Postoperative complications were characterised using a modified ...Continue Reading

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Citations

Dec 6, 2014·Urology·Ari Adamy
Sep 25, 2016·Annals of Surgical Oncology·François BrécheteauPierre Bigot
Aug 8, 2014·BJU International·Bl JacksonUNKNOWN British Association of Urological Surgeons (BAUS) - Section of Oncology
Apr 10, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Michael A FeuersteinPaul Russo
Apr 19, 2016·Annals of the Royal College of Surgeons of England·J M HendersonF X Keeley
Jun 5, 2018·The New England Journal of Medicine·Arnaud MéjeanBernard Escudier
Mar 15, 2020·Current Oncology Reports·Walter R HsiangMichael S Leapman

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