Systematic coarse-graining of spectrin-level red blood cell models

Computer Methods in Applied Mechanics and Engineering
D A FedosovG E Karniadakis

Abstract

We present a rigorous procedure to derive coarse-grained red blood cell (RBC) models, which yield accurate mechanical response. Based on a semi-analytic theory the linear and nonlinear elastic properties of healthy and infected RBCs in malaria can be matched with those obtained in optical tweezers stretching experiments. The present analysis predicts correctly the membrane Young's modulus in contrast to about 50% error in predictions by previous models. In addition, we develop a stress-free model which avoids a number of pitfalls of existing RBC models, such as non-smooth or poorly controlled equilibrium shape and dependence of the mechanical properties on the initial triangulation quality. Here we employ dissipative particle dynamics for the implementation but the proposed model is general and suitable for use in many existing continuum and particle-based numerical methods.

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Citations

Feb 22, 2012·Biomechanics and Modeling in Mechanobiology·F Fraternali, G Marcelli
Jan 15, 2014·Annals of Biomedical Engineering·Dmitry A FedosovSubra Suresh
Dec 24, 2013·Journal of Fluid Mechanics·Huan LeiGeorge Em Karniadakis
Dec 7, 2011·PLoS Computational Biology·Dmitry A FedosovGeorge E Karniadakis
Oct 23, 2013·PloS One·Gonghao WangTodd Sulchek
May 15, 2013·Biomechanics and Modeling in Mechanobiology·Dmitry A FedosovGerhard Gompper
Jan 23, 2016·Journal of the Royal Society, Interface·Alexandra WitthoftGeorge Em Karniadakis
Nov 4, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Dmitry A FedosovGeorge Em Karniadakis
Apr 16, 2016·Biomechanics and Modeling in Mechanobiology·L L XiaoB M Fu
Apr 19, 2016·Soft Matter·Alireza Yazdani, George Em Karniadakis
Mar 1, 2015·Microvascular Research·Dinar KatanovDmitry A Fedosov
Sep 10, 2013·Biophysical Journal·Ting YeChwee Teck Lim
May 5, 2011·Biophysical Journal·Dmitry A FedosovGeorge Em Karniadakis
Nov 18, 2015·International Journal for Numerical Methods in Biomedical Engineering·Iveta Jančigová, Ivan Cimrák
Oct 16, 2016·Biomechanics and Modeling in Mechanobiology·L L XiaoB M Fu
Apr 23, 2014·Soft Matter·Dmitry A FedosovGerhard Gompper
Feb 28, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Achim Guckenberger, Stephan Gekle
Jul 18, 2018·Soft Matter·Masoud HooreDmitry A Fedosov
May 2, 2018·Journal of Biomechanical Engineering·Faisal AhmedCyrus K Aidun
Feb 19, 2015·Annals of Biomedical Engineering·Hussein M EzzeldinElias Balaras
Jul 13, 2019·Biomechanics and Modeling in Mechanobiology·L L XiaoW W Yan
Jun 5, 2019·Biomechanics and Modeling in Mechanobiology·Ting YeGuansheng Li
Apr 4, 2014·Soft Matter·Dmitry A Fedosov, Gerhard Gompper
Aug 22, 2017·Frontiers in Physiology·Gábor ZávodszkyAlfons Hoekstra
Oct 3, 2019·Journal of the Royal Society, Interface·B J M van RooijA G Hoekstra
Nov 22, 2019·Biomechanics and Modeling in Mechanobiology·Paul Van LiedekerkeDirk Drasdo
Jun 23, 2020·Soft Matter·Fabio GugliettaMauro Sbragaglia
Aug 19, 2020·Biomechanics and Modeling in Mechanobiology·Jingyu CuiBingmei M Fu
Oct 30, 2016·PLoS Computational Biology·Hung-Yu ChangGeorge Em Karniadakis
May 5, 2017·Biomechanics and Modeling in Mechanobiology·Julien SigüenzaFranck Nicoud
Oct 29, 2017·Scientific Reports·Kathrin RackGerhard Gompper
Jun 17, 2018·The Journal of Chemical Physics·Toru YamadaShinji Tamano
Mar 18, 2016·Physical Review. E·Marmar MehrabadiCyrus K Aidun

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