Systematic comparison of methods for determining the in vivo biodistribution of porous nanostructured injectable inorganic particles

Acta Biomaterialia
Sara NizzeroMauro Ferrari

Abstract

With a wide variety of biodistribution measurement techniques reported in the literature, it is important to perform side-by-side comparisons of results obtained with different methods on the same particle platform, to determine differences across methods, highlight advantages and disadvantages, and inform methods selection according to specific applications. Inorganic nanostructured particles (INPs) have gained a central role in the development of injectable delivery vectors thanks to their controllable design, biocompatibility, and favorable degradation kinetic. Thus, accurate determination of in vivo biodistribution of INPs is a key aspect of developing and optimizing this class of delivery vectors. In this study, a systematic comparison of spectroscopy (inductively coupled plasma optical emission spectroscopy), fluorescence (in vivo imaging system, confocal microscopy, and plate reader), and radiolabeling (gamma counter)-based techniques is performed to assess the accuracy and sensitivity of biodistribution measurements in mice. Each method is evaluated on porous silicon particles, an established and versatile injectable delivery platform. Biodistribution is evaluated in all major organs and compared in terms of absolute re...Continue Reading

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Citations

Apr 22, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Prashant DograZhihui Wang
Jan 26, 2021·Chemical Society Reviews·Juan PellicoRafael T M de Rosales
Jan 19, 2020·Trends in Cancer·Sara NizzeroBruna Corradetti
Jun 20, 2020·ACS Applied Materials & Interfaces·Mikhail V ZyuzinAlexander S Timin

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