Systematic feasibility analysis of performing elastography using reduced dose CT lung image pairs

Medical Physics
Katelyn HasseAnand P Santhanam

Abstract

Elastography using computer tomography (CT) is a promising methodology that can provide patient-specific regional distributions of lung biomechanical properties. The purpose of this paper is to investigate the feasibility of performing elastography using simulated lower dose CT scans. A cohort of eight patient CT image pairs were acquired with a tube current-time product of 40 mAs for estimating baseline lung elastography results. Synthetic low mAs CT scans were generated from the baseline scans to simulate the additional noise that would be present in acquisitions at 30, 25, and 20 mAs, respectively. For the simulated low mAs scans, exhalation and inhalation datasets were registered using an in-house optical flow deformable image registration algorithm. The registered deformation vector fields (DVFs) were taken to be ground truth for the elastography process. A model-based elasticity estimation was performed for each of the reduced mAs datasets, in which the goal was to optimize the elasticity distribution that best represented their respective DVFs. The estimated elasticity and the DVF distributions of the reduced mAs scans were then compared with the baseline elasticity results for quantitative accuracy purposes. The DVFs fo...Continue Reading

References

Jan 24, 2008·AJR. American Journal of Roentgenology·Takeshi KuboHiroto Hatabu
May 20, 2008·Respiratory Physiology & Neurobiology·Béla Suki, Jason H T Bates
Jun 21, 2008·Radiology·Fred A MettlerMahadevappa Mahesh
Nov 30, 2012·Clinical Science·Bethan L Barker, Christopher E Brightling
May 4, 2013·Physics in Medicine and Biology·Daniel A LowJames M Lamb
Jan 15, 2014·International Journal of Computer Assisted Radiology and Surgery·Yugang MinAnand P Santhanam
Nov 5, 2016·Physics in Medicine and Biology·D H ThomasD A Low

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