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Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

Genome Biology

Feb 26, 2015

OZGUN BABUREmek Demir

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Abstract

We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in t...read more

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References
    • References24
    • Citations33
    • References24
    • Citations33
  • Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

    Genome Biology

    Feb 26, 2015

    OZGUN BABUREmek Demir

    PMID: 25887147

    DOI: 10.1186/s13059-015-0612-6

    Abstract

    We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in t...read more

    41
    1
    129
    Paper Details
    References
    • References24
    • Citations33
    • References24
    • Citations33
  • Get paper from

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