Systematic Identification of lncRNA-Associated ceRNA Networks in Immune Thrombocytopenia.

Computational and Mathematical Methods in Medicine
Zhenwei FanYan Song

Abstract

Primary immune thrombocytopenia (ITP) is an autoimmune disease. However, the molecular mechanisms underlying ITP remained to be further investigated. In the present study, we analyzed a series of public datasets (including GSE43177 and GSE43178) and identified 468 upregulated mRNAs, 272 downregulated mRNAs, 134 upregulated lncRNAs, 23 downregulated lncRNAs, 29 upregulated miRNAs, and 39 downregulated miRNAs in ITP patients. Then, we constructed protein-protein interaction networks, miRNA-mRNA and lncRNA coexpression networks in ITP. Bioinformatics analysis showed these genes regulated multiple biological processes in ITP, such as mRNA nonsense-mediated decay, translation, cell-cell adhesion, proteasome-mediated ubiquitin, and mRNA splicing. We thought the present study could broaden our insights into the mechanism underlying the progression of ITP and provide a potential biomarker for the prognosis of ITP.

References

Mar 15, 2005·Journal of Autoimmune Diseases·Dimitry A Chistiakov
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
May 17, 2013·Seminars in Hematology·Karina YazdanbakhshWeili Bao
May 8, 2014·British Journal of Haematology·Haifeng ZhaoRenchi Yang
Feb 11, 2015·Trends in Pharmacological Sciences·Michael A Frohman
Sep 7, 2018·Experimental and Therapeutic Medicine·Lei ChenYeqing Sun

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Datasets Mentioned

BETA
GSE43177
GSE43178

Methods Mentioned

BETA
CLIP-Seq

Software Mentioned

STRING
Search Tool for the Retrieval of Interacting Genes / Proteins ...
GEO2R
Cytoscape
MAS
TargetScan
PicTar

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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