Systematic Integration of Structural and Functional Data into Multi-scale Models of Mouse Primary Visual Cortex

Neuron
Yazan N BillehAnton Arkhipov

Abstract

Structural rules underlying functional properties of cortical circuits are poorly understood. To explore these rules systematically, we integrated information from extensive literature curation and large-scale experimental surveys into a data-driven, biologically realistic simulation of the awake mouse primary visual cortex. The model was constructed at two levels of granularity, using either biophysically detailed or point neurons. Both variants have identical network connectivity and were compared to each other and to experimental recordings of visual-driven neural activity. While tuning these networks to recapitulate experimental data, we identified rules governing cell-class-specific connectivity and synaptic strengths. These structural constraints constitute hypotheses that can be tested experimentally. Despite their distinct single-cell abstraction, both spatially extended and point models perform similarly at the level of firing rate distributions for the questions we investigated. All data and models are freely available as a resource for the community.

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Citations

Mar 11, 2020·PLoS Computational Biology·Jan-Eirik W SkaarGaute T Einevoll
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Aug 7, 2021·Proceedings of the National Academy of Sciences of the United States of America·Logan CharikerLai-Sang Young
Aug 17, 2021·PLoS Computational Biology·Anton V Chizhov, Lyle J Graham

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