Systematic Investigation of Molecular Recognition Ability in FET-based Chemical Sensors Functionalized with a Mixed Self-Assembled Monolayer System

ACS Applied Materials & Interfaces
Tsukuru MinamikiRyoji Kurita

Abstract

Exploring new strategies for simple and on-demand methods of manipulating the sensing ability of sensor devices functionalized with artificial receptors embedded in a molecular assembly is important to realizing high-throughput on-site sensing systems based on integrated and miniaturized devices such as field-effect transistors (FETs). Although FET-based chemical sensors can be used for rapid, quantitative, and simultaneous determination of various desired analytes, detectable targets in conventional FET sensors are currently restricted owing to the complicated processes used to prepare sensing materials. In this study, we investigated the relationship between the sensing features of FETs and the nanostructures of mixed self-assembled monolayers (mSAMs) for the detection of biomolecules. The FET devices were systematically functionalized using mixtures of benzenethiol derivatives (4-mercaptobenzoic acid and benzenethiol), which changed the nanostructure of the SAMs formed on gold sensing electrodes. The obtained cross-reactivity in the FETs modified with the mSAMs was derived from the multidimensional variations of the SAM characteristics. Our successful demonstration of continuous control of the molecular recognition ability i...Continue Reading

References

Jun 29, 1999·Analytical Chemistry·D S Hage
Mar 11, 2003·Biomacromolecules·Emek SeyrekElizabeth A Gamble
Aug 16, 2003·Analytical Chemistry·Vladimir L AlexeevSanford A Asher
Nov 20, 2003·Journal of the American Chemical Society·Naomi Sakai, Stefan Matile
Sep 16, 2004·Journal of the American Chemical Society·Corinne L D Gibb, Bruce C Gibb
Jun 9, 2005·Journal of the American Chemical Society·Ryuhei Nishiyabu, Pavel Anzenbacher
Sep 24, 2005·Clinical Chemistry·Rudolf M Lequin
Apr 28, 2006·Journal of the American Chemical Society·Toby L NelsonJohn J Lavigne
Jul 28, 2006·Nature·Dirk JanasekAndreas Manz
Apr 14, 2007·Journal of the American Chemical Society·Jinjun ShiPaul S Cremer
May 29, 2007·Journal of the American Chemical Society·Manuel A PalaciosPavel Anzenbacher
Jul 20, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·David BarrietT Randall Lee
Feb 21, 2008·Analytical and Bioanalytical Chemistry·A Q LiuX C Li
Nov 1, 2009·Nature Chemistry·Ismael Díez-PérezNongjian Tao
Apr 29, 2011·Journal of the American Chemical Society·Corinne L D Gibb, Bruce C Gibb
Jul 22, 2011·Nature·Jonathan M RothbergJames Bustillo
Oct 21, 2011·ACS Nano·Shannon K YeeRachel A Segalman
Jul 10, 2012·Chemical Society Reviews·Katsuhiko ArigaHiroshi Tsukube
Feb 20, 2013·Chemical Society Reviews·Anthony P F Turner
May 15, 2013·Chemistry : a European Journal·Pavel AnzenbacherRyuhei Nishiyabu
Jun 25, 2014·Nature Communications·Amir LichtensteinFernando Patolsky
Jul 15, 2015·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Tsuyoshi MinamiShizuo Tokito
Nov 14, 2015·Chemical Reviews·Steven J BarrowOren A Scherman
Jul 8, 2016·ACS Nano·Nisreen ShehadaHossam Haick
Jun 1, 2018·Chemical Communications : Chem Comm·Tsukuru MinamikiTsuyoshi Minami
Jun 23, 2018·Science·L FumagalliA K Geim
Sep 13, 2018·Chemical Reviews·Zheng LiKenneth S Suslick
Sep 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jinghua LiJohn A Rogers
Apr 27, 2019·Journal of the American Chemical Society·Jennifer F NealHeather C Allen
May 24, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Sing Yee YeungBörje Sellergren
Aug 3, 2019·NPJ Digital Medicine·Dhruv R SeshadriColin K Drummond

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
T VoitsekhivskaG Cuniberti
Journal of Applied Physiology
R A Ganfield, D E Laughlin
© 2021 Meta ULC. All rights reserved