Systematic Investigation of the Effect of Non-Ionic Emulsifiers on Skin by Confocal Raman Spectroscopy-A Comprehensive Lipid Analysis

Pharmaceutics
Yali Liu, Dominique Jasmin Lunter

Abstract

Non-ionic emulsifiers are commonly found in existing pharmaceutical and cosmetic formulations and have been widely employed to enhance the penetration and permeation of active ingredients into the skin. With the potential of disrupting skin barrier function and increasing fluidity of stratum corneum (SC) lipids, we herein examined the effects of two kinds of non-ionic emulsifiers on intercellular lipids of skin, using confocal Raman spectroscopy (CRS) with lipid signals on skin CRS spectrum. Non-ionic emulsifiers of polyethylene glycol alkyl ethers and sorbitan fatty acid esters were studied to obtain a deep understanding of the mechanism between non-ionic emulsifiers and SC lipids. Emulsifier solutions and dispersions were prepared and applied onto excised porcine skin. Water and sodium laureth sulfate solution (SLS) served as controls. SC lipid signals were analysed by CRS regarding lipid content, conformation and lateral packing order. Polyethylene glycol (PEG) sorbitan esters revealed no alteration of intercellular lipid properties while PEG-20 ethers appeared to have the most significant effects on reducing lipid content and interrupting lipid organization. In general, the polyoxyethylene chain and alkyl chain of PEG deriv...Continue Reading

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Citations

Sep 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Richard Krombholz, Dominique Lunter
Apr 5, 2020·Pharmaceutics·Dominique Jasmin Lunter, Rolf Daniels
Jan 13, 2021·Pharmaceutics·Richard KrombholzDominique Jasmin Lunter
Jun 4, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yali Liu, Dominique Jasmin Lunter

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Methods Mentioned

BETA
X-ray
PCA

Software Mentioned

WITec
WITec Project
GraphPad Prism
GraphPad
MatLab

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