Systematic Literature Review of AbobotulinumtoxinA in Clinical Trials for Lower Limb Spasticity

Medicine
Khashayar DashtipourMichael Y Lee

Abstract

To elucidate clinical trial efficacy, safety, and dosing practices of AbobotulinumtoxinA (ABO) treatment in adult patients with lower limb spasticity.A systematic literature review was performed to identify randomized controlled trials of ABO in the treatment of adult lower limb spasticity.Of the 295 records identified, 6 primary publications evaluated ABO for the management of lower limb spasticity of various etiologies and were evaluated. Total ABO doses ranged between 500 and 2000 U for lower limb spasticity, depending on the muscles injected. All studies in lower limb spasticity showed statistically significant reduction in muscle tone based on Modified Ashworth Scale of ABO versus placebo. Significant effects on active movement and pain were demonstrated albeit less consistently. ABO was generally well tolerated across the individual studies; most adverse events reported were considered unrelated to treatment. Treatment-related adverse events included but not limited to fatigue, local pain at injection site, hypertonia, dry mouth, weakness of the noninjected muscle, abnormal gait, and urinary tract infection.These data from 6 randomized clinical studies provide the beginnings of an evidence base for the use of ABO to reduc...Continue Reading

References

Apr 1, 2005·Disability and Rehabilitation·J H BurridgeA D Pandyan
May 26, 2006·International Wound Journal·Bishara S Atiyeh, Shady N Hayek
Feb 6, 2008·Journal of Rehabilitation Research and Development·Mark G Bowden, Andrea L Behrman
Dec 27, 2008·The Keio Journal of Medicine·Yukihiro Hara
Feb 7, 2009·Journal of Rehabilitation Medicine·Jörg WisselNiko Tieranta
Oct 25, 2011·Journal of the Neurological Sciences·S H SubramonyA Tan
Dec 12, 2012·Toxicon : Official Journal of the International Society on Toxinology·Alberto EsquenaziAnthony B Ward
Oct 10, 2014·American Journal of Physical Medicine & Rehabilitation·Khashayar DashtipourMichael Y Lee

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Citations

Jun 8, 2018·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Juan Avendano-CoyJulio Gomez-Soriano
Oct 30, 2018·Journal of Computer Assisted Tomography·John CiancaKatherine H Taber
Aug 14, 2019·PM & R : the Journal of Injury, Function, and Rehabilitation·Steven KirshblumAmanda Botticello
Oct 20, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A P Kovalenko, V K Misikov
Nov 23, 2017·The Cochrane Database of Systematic Reviews·Anneliese SynnotKate Phillips
Aug 3, 2020·PM & R : the Journal of Injury, Function, and Rehabilitation·Alberto EsquenaziJean-Michel Gracies

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Clinical Trials Mentioned

NCT01249404
NCT01251367

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