Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions

The Journal of Comparative Neurology
Michael R AkinsJustin R Fallon


Loss of Fragile X mental retardation protein (FMRP) leads to Fragile X syndrome (FXS), the most common form of inherited intellectual disability and autism. Although the functions of FMRP and its homologs FXR1P and FXR2P are well studied in the somatodendritic domain, recent evidence suggests that this family of RNA binding proteins also plays a role in the axonal and presynaptic compartments. Fragile X granules (FXGs) are morphologically and genetically defined structures containing Fragile X proteins that are expressed axonally and presynaptically in a subset of circuits. To further understand the role of presynaptic Fragile X proteins in the brain, we systematically mapped the FXG distribution in the mouse central nervous system. This analysis revealed both the circuits and the neuronal types that express FXGs. FXGs are enriched in circuits that mediate sensory processing and motor planning-functions that are particularly perturbed in FXS patients. Analysis of FXG expression in the hippocampus suggests that CA3 pyramidal neurons use presynaptic Fragile X proteins to modulate recurrent but not feedforward processing. Neuron-specific FMRP mutants revealed a requirement for neuronal FMRP in the regulation of FXGs. Finally, cond...Continue Reading


Oct 15, 1978·The Journal of Comparative Neurology·L W SwansonW M Cowan
Sep 1, 1976·The Journal of Comparative Neurology·J W Hinds, P L Hinds
Aug 1, 1975·The Journal of Comparative Neurology·E G Jones
May 22, 1990·The Journal of Comparative Neurology·N IshizukaD G Amaral
Mar 1, 1985·European Journal of Pediatrics·R H Largo, A Schinzel
Nov 22, 1994·The Journal of Comparative Neurology·I StepniewskaJ H Kaas
Mar 5, 2002·Human Molecular Genetics·Carola J M BontekoeBen A Oostra
Jul 12, 2002·Microscopy Research and Technique·Alice S M KauWalter E Kaufmann
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisa A GabelJustin R Fallon
Mar 31, 2005·Journal of Autism and Developmental Disorders·David CohenDelphine Héron
Oct 29, 2005·Journal of Neuropathology and Experimental Neurology·Jane Pickett, Eric London
Nov 1, 2005·Neurobiology of Disease·E J MientjesB A Oostra
Dec 2, 2005·The Journal of Comparative Neurology·Michael R Akins, Charles A Greer
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jesse E Hanson, Daniel V Madison
Apr 9, 2008·Physiological Reviews·Antonio GiudittaMarianna Crispino
Apr 11, 2008·Physical & Occupational Therapy in Pediatrics·Grace T BaranekDonald B Bailey
Sep 6, 2008·Journal of Intellectual Disability Research : JIDR·C ZingerevichR J Hagerman
Dec 17, 2008·Journal of Pediatric Psychology·Jane E RobertsDonald B Bailey
Jan 17, 2009·Neuron·Mauro Costa-MattioliNahum Sonenberg
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean B ChristieJustin R Fallon
Feb 27, 2009·Journal of Neurophysiology·Jing ZhangDavid L Nelson
May 15, 2009·American Journal of Medical Genetics. Part a·R Nick HernandezWalter E Kaufmann
Oct 20, 2009·Frontiers in Neural Circuits·R Suzanne ZukinClaudia Bagni
Nov 17, 2009·Frontiers in Neural Circuits·Michael R AkinsJustin R Fallon
Dec 17, 2009·PLoS Genetics·Julie B ZangRobert B Darnell
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Fumiko HoeftAllan L Reiss
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pan-Yue DengVitaly A Klyachko
Oct 19, 2011·Behavioral Neuroscience·Snigdha RoyDetlef H Heck
Feb 14, 2012·Human Molecular Genetics·Sally M TillPeter C Kind

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