Systematic meta-analysis of genetic variants associated with osteosarcoma susceptibility

Medicine
Xinjia Wang, Zhenyu Liu

Abstract

In the past decade, accumulated evidence has suggested that genetic variation is related to the pathogenesis of osteosarcoma. Although there are a large number of studies on the association between genetic variation and osteosarcoma, their results are inconsistent. To clarify these findings, we performed a systematic meta-analysis using allelic contrasts for each gene-specific single nucleotide variants with all available data in the field of osteosarcoma. The literature search for relevant studies was conducted in PubMed, Embase, and Cochrane databases. Pooled ORs and 95% CI values were calculated by the random-effects model using the Comprehensive Meta-analysis version 2.0 software package. Heterogeneity between studies was examined by the Cochran's Q-test. The 32 genome-wide case-control population-based studies, involving 15,336 study subjects (6924 cases and 8412 controls), were included in this meta-analysis. We analyzed 24 single nucleotide variants (SNVs) in 14 genes. We identified 12 SNVs in CTLA-4, IL-8, MDM2, PRCKG, RECQL5, TNF-a, TP53, XRCC3, and VEGF that correlated with osteosarcoma susceptibility. The average pooled odds ratio for the 9 risk alleles was 2.082 (range: 1.585 to 3.262). These included CTLA-4 rs23177...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jan 24, 1998·Lancet·J LauC H Schmid
Aug 18, 2004·Trends in Genetics : TIG·Marcus R Munafò, Jonathan Flint
Nov 12, 2005·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A E AdesJ P T Higgins
May 2, 2008·Current Treatment Options in Oncology·Stefan S BielackMichael Paulussen
Aug 30, 2008·Paediatric Drugs·Alexander J ChouRichard Gorlick
Mar 26, 2011·Sarcoma·Sharon A Savage, Lisa Mirabello
Apr 6, 2011·Cancer Causes & Control : CCC·Lisa MirabelloSharon A Savage
Sep 14, 2011·International Journal of Cancer. Journal International Du Cancer·Jeremy WhelanSandra J Strauss
Oct 20, 2012·The Journal of Bone and Joint Surgery. American Volume·Joseph H SchwabFrancis J Hornicek
Jul 21, 2016·Pediatric Research·Nerea Bilbao-AldaiturriagaAfrica Garcia-Orad

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BETA
surgical resection

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Comprehensive Meta - analysis

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