Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster.

C. Nava GonzalesChih-Ying Su


The biophysical properties of sensory neurons are influenced by their morphometric and morphological features, whose precise measurements require high-quality volume electron microscopy (EM). However, systematic surveys of nanoscale characteristics for identified neurons are scarce. Here, we characterize the morphology of Drosophila olfactory receptor neurons (ORNs) across the majority of genetically identified sensory hairs. By analyzing serial block-face electron microscopy images of cryofixed antennal tissues, we compile an extensive morphometric data set based on 122 reconstructed 3D models for 33 of the 40 identified antennal ORN types. Additionally, we observe multiple novel features-including extracellular vacuoles within sensillum lumen, intricate dendritic branching, mitochondria enrichment in select ORNs, novel sensillum types, and empty sensilla containing no neurons-which raise new questions pertinent to cell biology and sensory neurobiology. Our systematic survey is critical for future investigations into how the size and shape of sensory neurons influence their responses, sensitivity, and circuit function.


Jan 1, 1986·Annual Review of Neuroscience·K E Kaissling
Jan 1, 1996·Journal of Structural Biology·J R KremerJ R McIntosh
Jun 8, 2001·Neuron·M de BruyneJ R Carlson
Jan 5, 2002·Microscopy Research and Technique·S R ShanbhagR A Steinbrecht
Jun 24, 2004·Cell·Elissa A HallemJohn R Carlson
Sep 6, 2005·Current Biology : CB·Africa CoutoBarry J Dickson
Sep 6, 2005·Current Biology : CB·Elane Fishilevich, Leslie B Vosshall
Sep 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·C Andrea YaoJohn R Carlson
Apr 18, 2006·Cell·Elissa A Hallem, John R Carlson
Aug 25, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tal Soo Ha, Dean P Smith
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jae Young KwonJohn R Carlson
Mar 17, 2007·Current Biology : CB·Wynand van der Goes van Naters, John R Carlson
Sep 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ana F SilberingRichard Benton
Mar 27, 2012·Nature Neuroscience·Daniela FlueggeMarc Spehr
Nov 23, 2012·Nature·Chih-Ying SuJohn R Carlson
Dec 10, 2013·Current Biology : CB·Hany K M DweckMarcus C Stensmyr
Mar 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David S RonderosDean P Smith
May 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hany K M DweckBill S Hansson
Nov 16, 2016·ELife·Nikki K LarterJohn R Carlson
Jan 24, 2017·Neuron·Lucia L Prieto-GodinoRichard Benton
Apr 26, 2017·Annual Review of Neuroscience·Susy M KimJing W Wang
Apr 7, 2019·Nature Communications·Ye ZhangChih-Ying Su
Apr 13, 2019·Open Biology·Jennifer S SunJohn R Carlson
Jun 11, 2021·Current Biology : CB·Alina VulpeKaren Menuz
Nov 8, 2020·BioRxiv : the Preprint Server for Biology·D. TaskChristopher John Potter

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