Systematic MRI in NF1 children under six years of age for the diagnosis of optic pathway gliomas. Study and outcome of a French cohort

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
G BlanchardNF France network

Abstract

Optic pathway glioma (OPG) is the most common central nervous system tumor in children with neurofibromatosis type 1 (NF1), affecting 15-20% of patients. We reviewed the medical records of children systematically screened by ophthalmologic and MRI examinations to determine the influence of screening on the therapeutic management of children with OPG. Data were collected on 306 newly diagnosed cases screened with systematic MRI from January 2001 to July 2007. In the OPG group, we distinguished the asymptomatic or symptomatic groups according to their initial status. Forty-five patients had confirmed OPG (14.7%). Thirty-six patients (80%) were asymptomatic and nine (20%) were symptomatic at the time of diagnosis with visual symptoms in six cases. The average age at OPG diagnosis was 3.4 years with six patients (13%) over six years old. Average follow-up was 7.7 years. Progression was observed in 16 cases (35%). Most patient conditions were managed conservatively (87%). Six children (13%) were treated with chemotherapy due to worsening visual function. All of these children had severe or mild visual impairment at the end of follow-up. Our study does not support a clear benefit of systematic MRI screening in NF1 children under six ...Continue Reading

References

May 1, 1989·The Journal of Pediatrics·R ListernickN B Esterly
Aug 1, 1984·Ophthalmology·R A LewisR P Whitford
Oct 31, 2002·Journal of Child Neurology·David Viskochil
Sep 5, 2003·American Journal of Medical Genetics. Part a·Allison KingDavid H Gutmann
Mar 17, 2004·Ophthalmology·Sureka ThiagalingamKathryn North
May 20, 2004·American Journal of Medical Genetics. Part a·M A BlazoS E Plon
Mar 28, 2007·Annals of Neurology·Robert ListernickDavid H Gutmann
Apr 20, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lucas MorenoStergios Zacharoulis
Aug 21, 2013·Pediatric Blood & Cancer·Evan Kalin-HajduLuis H Ospina
Nov 28, 2013·Neurology·Michael J FisherUNKNOWN REiNS International Collaboration
Jan 1, 2014·Annals of Neurology·Kelly A Diggs-AndrewsDavid H Gutmann
Jul 18, 2014·Lancet Neurology·Angela C Hirbe, David H Gutmann

❮ Previous
Next ❯

Citations

May 17, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Patrícia de Freitas DottoSolange Rios Salomão
Sep 28, 2018·Acta Ophthalmologica·Catherine CassimanIngele Casteels
Sep 22, 2018·International Ophthalmology Clinics·Shannon J Beres
Oct 27, 2018·Nature Reviews. Endocrinology·Albert BeckersAdrian F Daly
Jun 28, 2019·Current Opinion in Ophthalmology·Marybeth K FarazdaghiRobert A Avery
Oct 31, 2019·Ciência & saúde coletiva·Mariane Alves SilvaJuliana Farias de Novaes
Jul 7, 2020·Neuro-oncology·Amedeo A AziziUNKNOWN SIOPE NF1 OPG Nottingham, UK, Workshop 2014
Sep 8, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Magdalena KoczkowskaLudwine M Messiaen
Jun 24, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Peter de BlankKevin R Krull
Jul 10, 2020·Neuro-oncology Advances·Peter de BlankMichael J Fisher
Mar 4, 2017·Current Opinion in Ophthalmology·Nailyn RasoolMichael Kazim
Mar 21, 2020·Scientific Reports·Johanna UthoffJessica C Sieren
Jun 12, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ben ShoftyShlomi Constantini
Feb 24, 2017·Nature Reviews. Disease Primers·David H GutmannKimberly J Johnson
Dec 12, 2018·Nature Medicine·Fulvio D'AngeloAntonio Iavarone
Feb 6, 2020·Orphanet Journal of Rare Diseases·Christina BergqvistUNKNOWN NF France Network
Mar 14, 2020·Acta Neuropathologica Communications·Scott RyallCynthia Hawkins
Jul 10, 2020·Neuro-oncology Advances·Amanda De Andrade Costa, David H Gutmann
Oct 20, 2017·Pediatric Blood & Cancer·Soumen KhatuaRoger J Packer
Jun 12, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Eloïse Baudou, Yves Chaix
Jul 10, 2020·Neuro-oncology Advances·María Jesús Lobón-IglesiasEric Pasmant
Nov 13, 2020·Clinical and Experimental Dermatology·L Steele, A R Shipman
Jan 15, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Filiz HazanAjlan Tükün
Aug 31, 2019·Dermatologic Clinics·Benjamin Becker, Roy E Strowd
Mar 7, 2021·Cancers·Yusuke FunakoshiMasahiro Mizoguchi
Mar 30, 2021·Journal of Neurological Surgery. Part B, Skull Base·Edward J WladisLauren Weintraub
Oct 31, 2017·Survey of Ophthalmology·Michael KinoriJanice Lasky Zeid

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Related Papers

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Christina SchinderaMaja Steinlin
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
G BlanchardL Lion Francois
© 2022 Meta ULC. All rights reserved