PMID: 9437273Jan 23, 1998Paper

Systematic overview of co-proxamol to assess analgesic effects of addition of dextropropoxyphene to paracetamol

BMJ : British Medical Journal
A Li Wan Po, W Y Zhang

Abstract

To evaluate the comparative efficacy and tolerability of paracetamol-dextropropoxyphene combination and paracetamol through a systematic overview of randomised controlled trials. Systematic retrieval of trials of paracetamol-dextropropoxyphene, paracetamol, and placebo to allow pooling of results from head to head comparison trials and single active placebo controlled trials. 2231 patients with postsurgical pain, arthritis, and musculoskeletal pain reported in 26 randomised controlled trials. Sum of difference in pain intensity; response rate ratio and difference in response rate with response defined as moderate to excellent pain relief; and rate ratio and rate difference of side effects. The difference in pain intensity between paracetamol-dextropropoxyphene and paracetamol was 7.3% (95% confidence interval -0.2 to 14.9). The response rate ratio for the combination and paracetamol was 1.05 (0.8 to 1.3) on the basis of the head to head trials. Indirect comparisons produced quantitatively consistent results. Compared with placebo, the combination produced more dizziness (3.1; 1.1 to 8.9) whereas paracetamol resulted in more drowsiness (1.8; 1.1 to 2.9). On the basis of data on analgesic efficacy and acute safety in both head to...Continue Reading

Citations

Jun 3, 2006·Clinical Rheumatology·Richard M Langford
Apr 11, 2003·Current Psychiatry Reports·Margo L Schilling
Jan 11, 2001·Pharmacology & Therapeutics·R D MacPherson
Mar 28, 2003·Best Practice & Research. Clinical Rheumatology·Tore K Kvien, Kirsten Viktil
Jun 18, 2002·Journal of the American Geriatrics Society·UNKNOWN AGS Panel on Persistent Pain in Older Persons
Jun 26, 2004·The Clinical Journal of Pain·Perry G Fine
Nov 24, 2006·American Journal of Therapeutics·Robert L BarkinDiana S Barkin
Mar 11, 2011·JAAPA : Official Journal of the American Academy of Physician Assistants·Larissa DeDea
Jun 6, 2009·International Journal of Clinical Practice·S J EdwardsJ Borrill
Jun 26, 1998·BMJ : British Medical Journal·G W Hanks, K Forbes
May 14, 2003·BMJ : British Medical Journal·Keith HawtonJonathan Deeks
Nov 19, 2010·PloS One·Sarah DoneganCatrin Tudur-Smith
Jan 13, 2004·Drugs & Aging·Thorsten Nikolaus, Andrej Zeyfang
May 21, 2005·Drugs & Aging·David J Goldstein, Dennis C Turk
Mar 21, 2007·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Sarah SinghCharles F Seifert
Jul 30, 2014·European Journal of Clinical Pharmacology·Laurent BecquemontPhilippe Bertin
Feb 25, 2005·QJM : Monthly Journal of the Association of Physicians·S SimkinN Kapur
May 10, 2012·Expert Opinion on Pharmacotherapy·Robert B RaffaJoseph V Pergolizzi
Jul 10, 2012·Expert Opinion on Pharmacotherapy·Joseph L Schuller, Mori J Krantz
Oct 10, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Bryan D Hayes, Bruce D Anderson
Sep 26, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Nicholas D Bateman, Euan A Sandilands
Oct 26, 2010·Oral and Maxillofacial Surgery Clinics of North America·Richard P SzumitaNancy Just
Feb 10, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·I I Acosta-MadridM I Ortiz
May 11, 2007·Best Practice & Research. Clinical Anaesthesiology·Narinder Rawal
Aug 8, 2015·Pharmacoepidemiology and Drug Safety·Corey J HayesBradley C Martin
Jan 29, 2005·British Journal of Clinical Pharmacology·K HawtonN Kapur
Jul 17, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Bernard Bannwarth, Christophe Richez
Apr 29, 2008·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Daniel S Budnitz
May 21, 2008·British Journal of Clinical Pharmacology·Euan A Sandilands, D Nicolas Bateman
Mar 21, 2009·Fundamental & Clinical Pharmacology·Sabine GaubertJean-Louis Montastruc
Nov 22, 2007·Internal Medicine Journal·S-A PearsonD Henry
Nov 25, 2005·British Journal of Clinical Pharmacology·Cara UsherJohn Feely
Aug 4, 2009·Fundamental & Clinical Pharmacology·Khalid A J Al KhajaReginald P Sequeira
Feb 6, 2010·Journal of Clinical Pharmacology·Ophelia Q P YinMoses S S Chow
Feb 15, 2013·Pharmacoepidemiology and Drug Safety·Wayne A RayCharles Michael Stein
Oct 26, 2006·The American Journal of Geriatric Pharmacotherapy·Sachin J Kamal-BahlMark H Beers
Nov 1, 2005·The American Journal of Geriatric Pharmacotherapy·Sachin Kamal-BahlMark H Beers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.