Systematic reaction to electrolytic treatment of pig livers in vivo

ANZ Journal of Surgery
D P BerryG J Maddern

Abstract

Only a minority of secondary liver tumours are amenable to segmental resection and as a result, considerable research has been focused on developing ablative methods to destroy liver metastases. Many of these methods are limited by the development of a systemic inflammatory response mediated by cytokines such as interleukin-8 (IL-8) and tumour necrosis factor alpha (TNF-alpha). The aim of the present study was to determine if a systemic reaction occurred following electrolytic treatment of pig livers in vivo, by measuring biochemical indices of liver function and cytokines such as IL-8 and TNF-alpha. Seventeen white domestic pigs were subjected to varying electrolytic doses ranging from 100 C to 800 C. Blood samples were taken at hourly intervals before, during and after electrolysis. Blood parameters measured included markers of liver enzyme activity; albumin, alkaline phosphatase, gammaglutaryl transferase and aspartate transaminase. Cytokine response to electrolysis was measured using enzyme-linked immunosorbent assays for IL-8 and TNF-alpha. Aspartate transaminase levels showed a clear and progressive rise post-electrolysis peaking at 2 h post-procedure. IL-8 and TNF-alpha levels showed only very mild variation with no sign...Continue Reading

References

Jan 1, 1990·The Journal of Infectious Diseases·J G CannonB Chernow
Jun 9, 1988·The New England Journal of Medicine·H R MichieD W Wilmore
Oct 24, 1986·Science·K J TraceyJ D Albert
Jul 1, 1985·The British Journal of Surgery·I Taylor
May 1, 1995·Critical Care Medicine·J W ChristmanT S Blackwell
Jan 1, 1995·World Journal of Surgery·J ScheeleM Paul
Jan 1, 1994·CA: a Cancer Journal for Clinicians·C C BoringS Montgomery
Jul 9, 1998·Cryobiology·J S BagiaD L Morris
Sep 30, 1998·The British Journal of Surgery·G SchüderG Feifel
Sep 30, 1998·The British Journal of Surgery·G S RobertsonG J Maddern
Aug 1, 2000·AJR. American Journal of Roentgenology·J R Haaga
Sep 1, 2000·BMJ : British Medical Journal·M Michael, J R Zalcberg
Dec 20, 2000·The Journal of Surgical Research·K WashingtonW C Chapman
Feb 13, 2002·American Journal of Surgery·S L WongK M McMasters
Apr 26, 2002·The British Journal of Surgery·S A Wemyss-HoldenG J Maddern

❮ Previous
Next ❯

Citations

Apr 9, 2008·The Journal of Surgical Research·Christopher DobbinsGuy Maddern
Aug 28, 2010·ANZ Journal of Surgery·Gianpiero GravanteAshley R Dennison
May 1, 2016·The British Journal of Oral & Maxillofacial Surgery·Hao-Yan ZhongJi-Hong Zhao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.