Systematic Review: Anaesthetic Protocols and Management as Confounders in Rodent Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (BOLD fMRI)-Part A: Effects of Changes in Physiological Parameters

Frontiers in Neuroscience
Aline R SteinerRegula Bettschart-Wolfensberger

Abstract

Background: To understand brain function in health and disease, functional magnetic resonance imaging (fMRI) is widely used in rodent models. Because animals need to be immobilised for image acquisition, fMRI is commonly performed under anaesthesia. The choice of anaesthetic protocols and may affect fMRI readouts, either directly or via changing physiological balance, and thereby threaten the scientific validity of fMRI in rodents. Methods: The present study systematically reviewed the literature investigating the influence of different anaesthesia regimes and changes in physiological parameters as confounders of blood oxygen level dependent (BOLD) fMRI in rats and mice. Four databases were searched, studies selected according to pre-defined criteria, and risk of bias assessed for each study. Results are reported in two separate articles; this part of the review focuses on effects of changes in physiological parameters. Results: A total of 121 publications was included, of which 49 addressed effects of changes in physiological parameters. Risk of bias was high in all included studies. Blood oxygenation [arterial partial pressure of oxygen (paO2)], ventilation [arterial partial pressure of carbon dioxide (paCO2)] and arterial bl...Continue Reading

References

Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R BustoM D Ginsberg
May 1, 1985·British Journal of Anaesthesia·J C Dorlas, J A Nijboer
Apr 1, 1982·Respiration Physiology·M Brun-PascaudJ J Pocidalo
Dec 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·C F Cartheuser
May 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G D GrahamJ C Gore
Sep 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F PrielmeierJ Frahm
Mar 5, 1998·The American Journal of Physiology·D L Mattson
Mar 14, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C BockM Hoehn-Berlage
Mar 14, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W LinW J Powers
Apr 2, 1998·Journal of Pharmacological and Toxicological Methods·R J IrvineR Chan
Sep 4, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E W HsuJ R MacFall
Sep 18, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W LinW J Powers
Dec 5, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W LinW J Powers
May 7, 1999·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·E HempelK Sartor
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J F DunnM E Meyerand
Oct 14, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H ItohT Kobayashi
Dec 19, 2000·Magnetic Resonance Imaging·G C HoustonC L Huang
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y NakaoL Sokoloff
Apr 30, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sridhar S KannurpattiA G Hudetz
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael V DutkaJohn C Gore
Sep 10, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eric R CohenSeong-Gi Kim
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Feng LuoShi-Jiang Li
Feb 20, 2003·Magnetic Resonance Imaging·U I TuorB Tomanek
Apr 8, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kenneth SicardTimothy Q Duong
May 27, 2003·Journal of Magnetic Resonance Imaging : JMRI·Sridhar S KannurpattiA G Hudetz
Jan 1, 1964·The American Journal of Physiology·M REIVICH
Dec 4, 2003·NMR in Biomedicine·Sridhar S KannurpattiA G Hudetz
May 26, 2004·Brain Research·Sridhar S Kannurpatti, Bharat B Biswal
Feb 15, 2005·Magnetic Resonance Imaging·Nikos K Logothetis, Josef Pfeuffer
Sep 20, 2005·Journal of Neurology·H Bart van der WorpCor J Kalkman
Nov 10, 2005·Critical Care : the Official Journal of the Critical Care Forum·Maxime CannessonDidier Jacques
Apr 7, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G VanhoutteA Van der Linden
Jul 13, 2006·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Andrew L RivardRichard W Bianco
Dec 28, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Min QiaoUrsula I Tuor

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Citations

Apr 13, 2021·Frontiers in Neuroscience·Yujian DiaoIleana O Jelescu
May 27, 2021·Scientific Reports·Gergely SomogyiAndrás Czurkó

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Methods Mentioned

BETA
sedation
transgenic

Software Mentioned

DistillerSR
Scopus
SYRCLE
ARRIVE
rsfMRI
Prisma

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