Systematic review and meta-analysis of islet autotransplantation after total pancreatectomy in chronic pancreatitis patients

Endocrine Journal
Qian WuYi Miao

Abstract

Islet autotransplantation (IAT) is a viable treatment for patients with severe chronic pancreatitis, this modality may prevent brittle diabetes mellitus after pancreatectomy. This systematic review and meta-analysis was performed to evaluated the outcomes of IAT after TP and discuss the factors that may affect the efficacy of this procedure. MEDLINE, Embase, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from 1977 to 30 April 2014. Cohort Studies reported patients with IAT after TP were included. The studies and data were identified and extracted by two reviewers independently. Data were analyzed using STATA 12.0 and Comprehensive Meta AnalysisV2 software. Random effects model, meta-regression analysis, sensitivity analysis and publication bias were conducted to improve the comprehensive analysis. Twelve studies reporting the outcomes of 677 patients were included in this review. The insulin independent rate for IAT after TP at last follow-up was 3.72 per 100 person-years (95% CI: 1.00-6.44). The 30-day mortality was 2.1% (95% CI: 1.2-3.8%). The mortality at last follow-up was 1.09 per 100 person-years (95% CI: 0.21-1.97). Factors associated with incidence density of insulin indepe...Continue Reading

Associated Clinical Trials

Dec 28, 2020·Mohamed Ahmed Hassan Aly

References

Apr 1, 1978·The Surgical Clinics of North America·D E SutherlandJ S Najarian
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Mar 1, 1981·Annals of Surgery·J L CameronG D Zuidema
Oct 1, 1996·The Journal of Clinical Endocrinology and Metabolism·F C BrunicardiD Elahi
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jan 9, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S GourgiotisS Germanos
Dec 7, 2007·The Surgical Clinics of North America·Juan J BlondetDavid E R Sutherland
Mar 9, 2012·Journal of the American College of Surgeons·David E R SutherlandTimothy L Pruett
Mar 22, 2012·The British Journal of Surgery·K BramisA R Dennison
Jun 8, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·R M WalshB Hatipoglu
Aug 29, 2013·Cancer Letters·Andreia V PinhoIlse Rooman
Nov 22, 2013·World Journal of Gastroenterology : WJG·Asbjørn Mohr Drewes
Nov 22, 2013·World Journal of Gastroenterology : WJG·Christina BrockAsbjørn Mohr Drewes

❮ Previous
Next ❯

Citations

Jul 29, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhu-Zeng YinXi-Mo Wang
Oct 29, 2017·Current Treatment Options in Gastroenterology·Muhammad Shafqet, Kaveh Sharzehi
Oct 11, 2016·World Journal of Gastrointestinal Surgery·Hazem M ZakariaHoracio J Asbun
Oct 28, 2017·Head & Neck·Mahmoud SakrIbrahim Fathi
Jan 14, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·George K JohnEllen M Stein
Sep 9, 2016·Updates in Surgery·Marco Del ChiaroUrban Arnelo
Sep 30, 2018·Current Diabetes Reports·Mohammed E Al-SofianiRita Rastogi Kalyani
Apr 25, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Maisam Abu-El-HaijaMelena D Bellin
Mar 24, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yoshihide NannoMelena D Bellin
Jul 3, 2021·Journal of Clinical Medicine·Beata Jabłońska, Sławomir Mrowiec
Aug 20, 2017·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Yama IssaUNKNOWN Collaborators
Nov 9, 2021·Expert Opinion on Biological Therapy·Mohamed Ali ChaouchFabrizio Panaro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.