Systematic Review and Meta-Analysis of Response Rates and Diagnostic Yield of Screening for Type 2 Diabetes and Those at High Risk of Diabetes

PloS One
Kamlesh KhuntiMelanie J Davies

Abstract

Screening for type 2 diabetes (T2DM) and individuals at risk of diabetes has been advocated, yet information on the response rate and diagnostic yield of different screening strategies are lacking. Studies (from 1998 to March/2015) were identified through Medline, Embase and the Cochrane library and included if they used oral glucose tolerance test (OGTT) and WHO-1998 diagnostic criteria for screening in a community setting. Studies were one-step strategy if participants were invited directly for OGTT and two, three/four step if participants were screened at one or more levels prior to invitation to OGTT. The response rate and diagnostic yield were pooled using Bayesian random-effect meta-analyses. 47 studies (422754 participants); 29 one-step, 11 two-step and seven three/four-step were identified. Pooled response rate (95% Credible Interval) for invitation to OGTT was 65.5% (53.7, 75.6), 63.1% (44.0, 76.8), and 85.4% (76.4, 93.3) in one, two and three/four-step studies respectively. T2DM yield was 6.6% (5.3, 7.8), 13.1% (4.3, 30.9) and 27.9% (8.6, 66.3) for one, two and three/four-step strategies respectively. The number needed to invite to the OGTT to detect one case of T2DM was 15, 7.6 and 3.6 in one, two, and three/four-ste...Continue Reading

References

Apr 20, 2001·BMJ : British Medical Journal·N J Wareham, S J Griffin
Apr 12, 2002·Diabetes Research and Clinical Practice·Albert G B AmoahSamuel Adjei
Feb 1, 2003·Annals of Internal Medicine·Russell HarrisKathleen N Lohr
Mar 1, 2003·Diabetes Care·Jaana Lindström, Jaakko Tuomilehto
Jul 10, 2003·Diabetes Research and Clinical Practice·Marco MensinkEllen E Blaak
Jul 29, 2003·Diabetes Care·Charlotte GlümerUNKNOWN Inter99 study
Nov 25, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·P BotasF J Díaz-Cadórniga
Jan 30, 2004·Diabetes Care·Stephen ColagiuriUNKNOWN AusDiab
Apr 28, 2004·Australian and New Zealand Journal of Public Health·Daniel McAullayMatthew Knuiman
Jul 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·C GlümerK Borch-Johnsen
Jun 11, 2005·Diabetes Research and Clinical Practice·David SimmonsPaul Zimmet
Jun 25, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·A HussainS Vaaler
Jul 28, 2005·Asia-Pacific Journal of Public Health·H R RoohafzaR Kelishadi
Aug 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·A SandbaekJ S Christiansen
Sep 24, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·Y DongQ Qiao
Oct 26, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·T C SkinnerK Khunti
Nov 25, 2005·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Timo SaaristoJaakko Tuomilehto
Mar 4, 2006·BMJ : British Medical Journal·Karsten Juhl Jørgensen, Peter C Gøtzsche
May 30, 2006·Diabetes Research and Clinical Practice·V Usha MenonHarish Kumar
Aug 23, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·P E Heldgaard, S J Griffin
Dec 26, 2006·Diabetes Research and Clinical Practice·M A RahimS Vaaler
Feb 20, 2007·Diabetes Research and Clinical Practice·J A Al-Lawati, J Tuomilehto
Apr 28, 2007·Health Technology Assessment : HTA·N WaughA John
Nov 21, 2007·Occupational Medicine·Christoph OberlinnerAndreas Zober
Jan 29, 2008·Clinical Chemistry·Cas WeykampCarla Siebelder
Mar 13, 2008·Journal of General Internal Medicine·David C ZiemerLawrence S Phillips
Apr 23, 2008·BMJ : British Medical Journal·Clare L GilliesKamlesh Khunti
Apr 25, 2008·Diabetes Research and Clinical Practice·Jaana KarjalainenUrho M Kujala

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Citations

Mar 1, 2006·Preventive Medicine·Anne-Helen HardingNicholas J Wareham
Feb 2, 2017·Community Dentistry and Oral Epidemiology·Matthew NeidellBarbara Shearer
Feb 14, 2017·Lancet·Sudesna ChatterjeeMelanie J Davies
Nov 7, 2018·BMJ Open Diabetes Research & Care·Ingrid HeuchJohn-Anker Zwart

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