Systematic review and meta-analysis of the prognostic value of CXCR2 in solid tumor patients

Oncotarget
Yong YangDonglin Sun

Abstract

CXC chemokine receptor-2 (CXCR2) expression is associated with the prognosis of multiple cancers. We performed a meta-analysis to determine the association between the CXCR2 expression in tumor tissue and patient prognosis. We compiled related literature from PubMed, Embase, and Web of Science (last updated July 31, 2017). A total of 4012 patients with solid tumors from 21 studies were included to evaluate the association between CXCR2 and overall survival, recurrence-free survival, or disease-free survival. High CXCR2 expression was significantly associated with poor overall survival (pooled HR = 1.82; 95% CI = 1.63-2.03; P < 0.001), recurrence-free survival (pooled HR = 1.40; 95% CI = 1.21-1.62; P < 0.001), and disease-free survival (pooled HR = 1.89; 95% CI = 1.05-3.40; P = 0.033), especially in patients with digestive system neoplasms. Thus high CXCR2 expression in tumor tissue appears predictive of a poor prognosis in patients with solid tumors. Further studies will be required to determine whether CXCR2 blockade has a favorable effect on the prognosis of patients with cancer.

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Citations

May 29, 2018·Scientific Reports·Hila Ventura-BixenshpanerMichal Hershfinkel
Mar 23, 2021·Frontiers in Oncology·Yasser TabanaKhaled H Barakat
Jun 15, 2021·Frontiers in Cell and Developmental Biology·Xiaobei LiuXiawei Wei
Jun 30, 2021·Journal of Cancer Research and Clinical Oncology·Karen BräutigamFrank Köster

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