Systematic review and meta-analysis of transoral laser microsurgery in hypopharyngeal carcinoma

Laryngoscope Investigative Otolaryngology
Ciaran LaneNorbert Viallet

Abstract

Transoral laser microsurgery has been suggested as an alternative treatment modality for hypopharyngeal carcinoma. The purpose of this study is to systematically review the oncologic and functional outcomes of patients with hypopharyngeal carcinoma when treated with primary transoral laser microsurgery. A comprehensive literature search was performed using PRISMA methodology on OVID MEDLINE and EMBASE. Meta-analysis was completed for oncological outcomes. Six studies reported quality of life outcomes five reported oncologic outcomes. A median of 95% (range 0.83-0.98) patients achieving gastrostomy independence, a median of 3% (range 0%-6%) were tracheostomy dependent, and a median of 97% (Range 0.89-1.0) were able to preserve their larynx. Pooled five-year overall survival was 54% (CI, 0.50-0.58, I2 = 29%), pooled disease-specific survival was 72% (CI, 0.68-0.77, I2 = 46%), and pooled local control rate was 78% (CI, 0.72-0.85, I2 = 69%). Systematic review supports improvements in functional outcomes and oncologic outcomes with transoral laser microsurgery.

References

Sep 26, 1997·Archives of Otolaryngology--head & Neck Surgery·C M HoA P Yuen
Mar 3, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W SteinerM Kron
Apr 24, 2003·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Heinrich H Rudert, Steffen Höft
Apr 21, 2004·Archives of Otolaryngology--head & Neck Surgery·Jeffrey E TerrellSonia A Duffy
Apr 19, 2006·Archives of Otolaryngology--head & Neck Surgery·Enver OzerDavid E Schuller
Jul 11, 2006·The Laryngoscope·Bon Seok KooEun Chang Choi
Jan 16, 2007·BMJ : British Medical Journal·John Fletcher
Feb 21, 2007·Archives of Otolaryngology--head & Neck Surgery·Jürg KutterPhilippe Pasche
Dec 20, 2007·The Laryngoscope·Alexios MartinWolfgang Steiner
Apr 22, 2009·Archives of Otolaryngology--head & Neck Surgery·Mark W El-DeiryBevan Yueh
Jun 26, 2010·Journal of Surgical Oncology·Alexander D KaratzanisHeinrich Iro
Jul 9, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Stijn KeereweerEsther van Meerten
Jul 3, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C R LeemansUNKNOWN Subcommittee of Surgery of the EORTC Head and Neck Cooperative Group
Sep 16, 2014·The Laryngoscope·J Robert NewmanWilliam R Carroll
Nov 15, 2016·The Journal of Laryngology and Otology·P PracyR Goranova
Jun 19, 2017·International Journal of Clinical Oncology·Shigemichi IwaeKen-Ichi Nibu

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