Systematic review and meta-analysis of histopathological predictive factors for lymph node metastasis in T1 colorectal cancer

Journal of Gastroenterology
Hiroo WadaMakoto Akaike

Abstract

In this study we examined whether histopathological findings, specifically lymphatic vessel invasion identified by an anti-human podoplanin antibody, and several other factors are associated with lymph node metastasis in T1 colorectal cancer. We searched PubMed and Cochrane Library, and also handsearched relevant journals, for reports written in English and published between 1998 and 2012, utilizing combination headings, such as 'colorectal cancer,' 'lymph node metastasis,' and 'risk factors.' For the report to be included in our study, the following criteria had to be met: (1) data on the frequency of lymph node metastasis in T1 colorectal cancer in relation to histopathological factors were reported; (2) patients had undergone bowel resection and had histologically diagnosed T1 colorectal cancer; (3) lymphatic vessel invasion was identified by immunohistochemistry with an anti-human podoplanin antibody rather than by hematoxylin and eosin staining; (4) univariate and multivariate analyses were conducted. Studies investigating molecular markers were excluded. The independent predictive factors were confirmed in at least one study included in the meta-analysis in the present systematic review. Microsoft Excel 2013 for Windows w...Continue Reading

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Citations

Jul 18, 2015·Histopathology·Alhadi AlmangushIlmo Leivo
Oct 20, 2015·Human Pathology·Viktor H KoelzerAlessandro Lugli
Oct 4, 2015·Chinese Journal of Integrative Medicine·Qian-Qian LiangYong-Jun Wang
Jun 9, 2016·Langenbeck's Archives of Surgery·Erman AytacHermann Kessler
Sep 10, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tim D G BelderbosPeter D Siersema
May 27, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alessandro LugliPhil Quirke
Nov 23, 2017·World Journal of Surgical Oncology·Xing-Mao ZhangQiang He
Mar 30, 2016·World Journal of Gastrointestinal Surgery·Mark L H Ong, John B Schofield
Jan 24, 2018·World Journal of Gastroenterology : WJG·Zhen-Qiang SunWei-Tang Yuan
Jul 25, 2018·Archives of Pathology & Laboratory Medicine·Soo-Jin Cho, Sanjay Kakar
Oct 23, 2018·ANZ Journal of Surgery·Nikas SamuolisUgne Ringeleviciute
Sep 12, 2019·Archives of Pathology & Laboratory Medicine·Catherine E Hagen, Ayesha Farooq
Dec 16, 2019·International Journal of Colorectal Disease·Andreas H MarxTill S Clauditz
Apr 8, 2020·Clinical Endoscopy·Chan Hyuk ParkHoon Jai Chun
Jun 30, 2019·World Journal of Gastroenterology : WJG·Scarlet Fiona Brockmoeller, Nicholas Paul West
May 26, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chan Hyuk ParkHoon Jai Chun
Oct 14, 2020·Intestinal research·Chan Hyuk ParkHoon Jai Chun
Jul 11, 2021·The British Journal of Surgery·A L EbbehøjH G Smith
Jan 11, 2021·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jeonghyun KangKang Young Lee
Nov 6, 2021·Virchows Archiv : an International Journal of Pathology·Daisuke AizawaTadakazu Shimoda

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