Systematic review and meta-analysis of phosphodiesterase type 5 inhibitors for the treatment of female sexual dysfunction

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Liang GaoJiuhong Yuan

Abstract

Clinical studies evaluating the effectiveness and safety of phosphodiesterase type 5 inhibitors (PDE5is) for female sexual dysfunction have reported conflicting results. To systematically review evidence from studies comparing PDE5is with placebo in the treatment of female sexual dysfunction. Searches of PubMed, the Cochrane Library, and Embase databases were performed using the MeSH terms "females/female/women", "sexual", and "sildenafil/tadalafil/vardenafil/PDE5/PDE5i". All randomized controlled trials, available in English, published no later than January 28, 2015 comparing the effectiveness of PDE5is, or PDE5is in combination with other agents, with placebo in improving female sexual function were included. The inclusion criteria were met by 14 studies, which were analyzed by two reviewers. The randomized controlled trials included in the present study adopted different questionnaires for measuring sexual function; consequently, most of the data had to be considered separately rather than pooled. Generally, the use of PDE5is resulted in significant improvements in sexual function compared with placebo, with some studies demonstrating negative results. Pooled data regarding adverse events demonstrated significantly higher ra...Continue Reading

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Citations

Sep 27, 2018·Expert Opinion on Emerging Drugs·Melanie K MillerAnita H Clayton
Sep 16, 2020·Health Technology Assessment : HTA·Michael J CrawfordThomas Re Barnes
Aug 29, 2021·Acta Obstetricia Et Gynecologica Scandinavica·Carolyn E CestaPär Karlsson

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