Systematic Review and Meta-Analysis of Procalcitonin-Guidance Versus Usual Care for Antimicrobial Management in Critically Ill Patients: Focus on Subgroups Based on Antibiotic Initiation, Cessation, or Mixed Strategies

Critical Care Medicine
Simon W LamAbhijit Duggal

Abstract

Numerous studies have evaluated the use of procalcitonin guidance during different phases of antibiotics management (initiation, cessation, or a combination of both) in patients admitted to ICUs. Several meta-analyses have attempted to generate an overall effect of procalcitonin-guidance on patient outcomes. However, combining studies from different phases of antibiotics management may not be appropriate due to the risk of clinical heterogeneity. The purpose of this systematic review and meta-analysis was to evaluate the effect of procalcitonin-guided strategies in different phases of antibiotics use. We searched MEDLINE and EMBASE from inception until November 1, 2017. We included randomized controlled trials that evaluated procalcitonin guidance compared with usual care for management of antibiotics in critically ill adult patients. We extracted study details, patient characteristics, procalcitonin algorithm, and outcomes. We included 15 studies, from 1,624 abstracts identified based on our search strategy (three initiation, nine cessation, and three mixed). The pooled risk ratio for short-term mortality for the initiation, cessation, and mixed procalcitonin strategies were 1.00 (95% CI, 0.86-1.15,;p = 0.91), 0.87 (95% CI, 0....Continue Reading

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Citations

Apr 14, 2018·Critical Care Medicine·Andre C Kalil, Trevor C Van Schooneveld
Nov 28, 2018·The Journal of International Medical Research·Yu ZhangLi Jiang
Dec 7, 2018·Pharmacotherapy·David D LeedahlErin F Barreto
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Apr 26, 2019·Critical Care : the Official Journal of the Critical Care Forum·Jesus F Bermejo-MartinRaquel Almansa
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Dec 15, 2020·Critical Care Medicine·Erika P Plata-Menchaca, Ricard Ferrer

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