Systematic review and meta-analysis on the adjunctive use of host immune modulators in non-surgical periodontal treatment in healthy and systemically compromised patients.

Scientific Reports
Stefano CorbellaLuca Francetti

Abstract

Considering the central role of inflammation in the pathogenesis of periodontitis, the combination of NSPT with different agents that can modulate the host immune-inflammatory response has been proposed to enhance the outcomes of NSPT. The aim of this paper is to systematically review the literature on the efficacy of systemic host modulators (HMs) as adjuncts to non-surgical periodontal therapy (NSPT) in improving pocket depth (PD) reduction and clinical attachment level (CAL) gain in healthy and systemically compromised patients. RCTs with ≥ 3 months follow-up were independently searched by two reviewers. Meta-analysis was performed when ≥ 3 studies on the same HM were identified. The quality of the evidence was rated according to the GRADE approach to rate the certainty of evidence. 38 articles were included in the qualitative assessment and 27 of them were included in the meta-analysis. There is low/very low evidence that the adjunctive use of sub-antimicrobial dose of doxycicline, melatonin and the combination of omega-3 and low dose aspirin (in type 2 diabetic patients) to NSPT would improve PD and/or CAL. Conflicting evidence is available on the efficacy of probiotics. Future studies controlling for confounding factors, ...Continue Reading

References

Jul 1, 1992·Journal of Clinical Epidemiology·D FollmannJ Cutler
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1970·Journal of Periodontology·S TureskyI Glickman
Jun 6, 2003·Journal of Clinical Periodontology·G A Van der Weijden, M F Timmerman
Dec 1, 1963·Acta Odontologica Scandinavica·H LOE, J SILNESS
Dec 2, 2005·Statistics in Medicine·Keith R AbramsPaul C Lambert
Jan 16, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G EmingilS Cinarcik
Feb 28, 2007·Journal of Clinical Periodontology·Ian NeedlemanMartin Jarvis
Jan 2, 2008·Journal of Periodontology·C Alec YenAthena S Papas
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Jul 9, 2010·Current Opinion in Allergy and Clinical Immunology·Luigi TerraccianoHolger Schünemann
Aug 25, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M J Bown, A J Sutton
Nov 14, 2012·Acta Pharmacologica Sinica·Alina Elena PârvuMarian Aurel Taulescu
Dec 11, 2013·Periodontology 2000·Ali CekiciThomas E Van Dyke
Jul 1, 2014·Molecular Oral Microbiology·G Hajishengallis
Oct 2, 2015·Journal of Clinical Periodontology·Isabelle LalemanWim Teughels
Aug 2, 2017·Periodontology 2000·Filippo GrazianiDavid Herrera
Dec 6, 2017·PloS One·Yoshiaki NomuraHiromasa Yoshie
Jan 23, 2018·Journal of Dental Research, Dental Clinics, Dental Prospects·Mohammadtaghi ChitsaziArash Hashemzadeh
Aug 5, 2018·Journal of Clinical Periodontology·Marcos M InverniciMichel R Messora

❮ Previous
Next ❯

Software Mentioned

OpenGrey
GRADE
RevMan Review Manager
Grading Recommendations Assessment , Development and Evaluatio...
Greylit

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.