Systematic review and meta-analysis: sodium picosulfate/magnesium citrate vs. polyethylene glycol for colonoscopy preparation

European Journal of Clinical Pharmacology
Zheng JinBiao Gong

Abstract

Previous studies comparing sodium picosulfate/magnesium citrate (SPMC) with polyethylene glycol (PEG) drew inconsistent conclusions. We conducted a meta-analysis to compare the performance of the two agents for colonoscopy preparation. A search of randomized controlled trials (RCTs) up to July 2015 was acquired, using MEDLINE, EMBASE, the Cochrane Library, and Google Scholar. We calculated the pooled estimates of bowel cleanliness, polyp/adenoma detection rate (PDR/ADR), completion of preparation, willingness to repeat identical bowel preparation, and adverse events by using relative risk (RR) with random-effects models. A non-inferiority analysis was performed, comparing SPMC to PEG for bowel cleaning efficacy. A total of 25 RCTs were qualified for analysis. There was no statistically significant difference between the two agents in bowel cleanliness, but the effect direction showed a trend in favor of PEG (RR 0.93; 95 % CI 0.86-1.01, P = 0.07). The non-inferiority analysis demonstrated the non-inferiority of SPMC by retaining at least 90 % of the effect of PEG. Similarly, there was no significant difference between the two agents in PDR (RR 0.94; 95 % CI 0.82-1.08, P = 0.37) and ADR (RR 0.88; 95 % CI 0.74-1.05, P = 0.16). How...Continue Reading

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Citations

Nov 30, 2018·Current Opinion in Gastroenterology·Parth J ParekhDavid A Johnson
Feb 7, 2018·Current Treatment Options in Gastroenterology·Cristina C Rutherford, Audrey H Calderwood
Jan 12, 2019·World Journal of Gastrointestinal Endoscopy·Rodrigo Silva de Paula RochaEduardo Guimarães Hourneaux de Moura
Mar 20, 2020·Gastroenterology Research and Practice·Zhou HaibinYang Jianfeng
Nov 23, 2017·United European Gastroenterology Journal·Ilvy van LieshoutRené van der Hulst
Dec 30, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Renáta BorTamás Molnár
May 16, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Milou L M van RiswijkPeter D Siersema

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