Systematic review and meta-analysis: the incidence and prevalence of paediatric coeliac disease across Europe.

Alimentary Pharmacology & Therapeutics
Stephen E RobertsJohn G Williams

Abstract

Coeliac disease is one of the most prevalent immune-mediated gastrointestinal disorders in children. To review the incidence and prevalence of paediatric coeliac disease, and their trends, regionally across Europe, overall and according to age at diagnosis. Systematic review and meta-analysis from January 1, 1950 to December 31, 2019, based on PubMed, CINAHL and the Cochrane Library, searches of grey literature and websites and hand searching of reference lists. A total of 127 eligible studies were included. The prevalence of previously undiagnosed coeliac disease from screening surveys (histology based) ranged from 0.10% to 3.03% (median = 0.70%), with a significantly increasing annual trend (P = 0.029). Prevalence since 2000 was significantly higher in northern Europe (1.60%) than in eastern (0.98%), southern (0.69%) and western (0.60%) Europe. Large increases in the incidence of diagnosed coeliac disease across Europe have reached 50 per 100 000 person-years in Scandinavia, Finland and Spain. The median age at diagnosis increased from 1.9 years before 1990 to 7.6 since 2000. Larger increases in incidence were found in older age groups than in infants and ages <5 years. Paediatric coeliac disease incidence and prevalence have...Continue Reading

References

Sep 1, 1991·European Journal of Pediatrics·M CeccarelliC Ughi
Jun 1, 1991·Digestive Diseases and Sciences·U VoltaF B Bianchi
Jun 1, 1989·European Journal of Pediatrics·L GrecoS Auricchio
May 1, 1988·Acta paediatrica Scandinavica·M MäkiJ K Visakorpi
May 1, 1987·Archives of Disease in Childhood·F M StevensB McNicholl
Sep 1, 1987·Journal of Pediatric Gastroenterology and Nutrition·L StenhammarU Jansson
Mar 24, 1973·British Medical Journal·M MylotteB McNicholl
Jun 1, 1969·Journal of Medical Genetics·W M McCrae
Feb 28, 1981·Lancet·S SimilåK Kouvalainen
Nov 1, 1984·Journal of Pediatric Gastroenterology and Nutrition·C R KoninckxA S Peña
Jan 1, 1983·Annals of the New York Academy of Sciences·T P ChorzelskiV Kumar
Jul 1, 1982·Scottish Medical Journal·E A RifkindA Ferguson
Jan 1, 1981·Acta paediatrica Scandinavica·L Stenhammar, C G Johansson
Mar 1, 1995·FEMS Immunology and Medical Microbiology·R UiboT Kivik
Feb 1, 1995·Pediatric Research·E K GeorgeJ P Vandenbroucke
Jan 22, 1994·Lancet·C CatassiP L Giorgi
Dec 1, 1993·Acta Paediatrica·L StenhammarB Lindquist
Jul 1, 1993·Journal of Clinical Epidemiology·B Weile, P A Krasilnikoff
Jan 1, 1993·Acta Paediatrica·H A al-ObaidyB S Lindblad
Jul 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·B WeileP A Krasilnikoff
Feb 1, 1997·Archives of Disease in Childhood·H AscherB Kristiansson
May 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·H Ascher, B Kristiansson
May 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·E K GeorgeC J Mulder
Nov 26, 1997·Archives of Disease in Childhood·D N ChallacombeE E Wheeler
Nov 3, 1998·Archives of Disease in Childhood·H R JenkinsG L Swift
Dec 3, 1998·Gastroenterology·W DieterichD Schuppan
Jan 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·I R Korponay-SzabóT Szabó
Aug 25, 1999·Lancet·C G CsizmadiaS P Verloove-Vanhorick
Apr 6, 2000·European Journal of Gastroenterology & Hepatology·N D HawkesH R Jenkins
Sep 6, 2000·Scandinavian Journal of Gastroenterology·C CatassiG V Coppa
Aug 2, 2001·Digestive Diseases and Sciences·U VoltaC Tiribelli
Jul 12, 2002·Deutsche medizinische Wochenschrift·J HenkerW Leupold
Dec 20, 2002·Journal of Epidemiology and Community Health·A IvarssonL A Persson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Alimentary Pharmacology & Therapeutics
R McLoughlinC O'Morain
Archives of Disease in Childhood
H R JenkinsG L Swift
Romanian Journal of Gastroenterology
Ioan Sporea
Archives of Disease in Childhood
B McNichollP F Fottrell
© 2021 Meta ULC. All rights reserved