Systematic review and network meta-analysis: Comparative effectiveness of therapies for second-line Helicobacter pylori eradication

Journal of Gastroenterology and Hepatology
Yee Hui YeoTaiwan Gastrointestinal Disease and Helicobacter Consortium

Abstract

The eradication rate of Helicobacter pylori (H. pylori) has been declining over the past decades. A rescue plan is needed for increasing populations with treatment failure. However, the optimum second-line eradication regimen remains inconclusive. We conducted a network meta-analysis to assess the comparative effectiveness of second-line H. pylori eradication therapies and determine the optimum regimen. We searched electronic databases from January 2005 to February 2018 for randomized controlled trials assessing the effectiveness of second-line regimens in patients with persistent H. pylori infection after first-line treatment. Bayesian network meta-analysis was performed to combine the direct and indirect evidence and to investigate the rank order of second-line therapies. We also appraised the quality of evidence using Grading of Recommendations Assessment, Development, and Evaluation guidance. Twenty-six trials with 3628 participants who received second-line eradication therapy were identified. All regimens showed pooled eradication rates < 90%. Compared with 7-day triple therapy, quinolone-based (odds ratio [OR] 4.29, 95% credible interval [CrI] 1.67-12.12, surface under the cumulative ranking [SUCRA] 0.95), non-quinolone-b...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 11, 2002·The New England Journal of Medicine·Sebastian Suerbaum, Pierre Michetti
Sep 28, 2004·Statistics in Medicine·G Lu, A E Ades
Apr 13, 2007·Clinical Microbiology Reviews·Francis Mégraud, Philippe Lehours
May 1, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·David Y Graham, Akiko Shiotani
May 21, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Jeroen P JansenWiro Stam
Sep 5, 2008·PharmacoEconomics·Alex SuttonKeith Abrams
Nov 1, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S Di CaroA Gasbarrini
Sep 29, 2011·Current Opinion in Gastroenterology·Michael Selgrad, Peter Malfertheiner
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Aug 18, 2012·ISRN Gastroenterology·M GasparettoG Guariso
Nov 17, 2012·World Journal of Gastroenterology : WJG·Simona Di CaroStuart Bloom
Feb 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Xiao LiangHong Lu
Oct 8, 2013·PloS One·Anna ChaimaniGeorgia Salanti
Sep 26, 2014·BMJ : British Medical Journal·Milo A PuhanUNKNOWN GRADE Working Group
Dec 24, 2015·Alimentary Pharmacology & Therapeutics·I ThungM A Valasek
Apr 23, 2016·Gastroenterology·Carlo A FalloneJohn K Marshall
Oct 23, 2016·Lancet·Jyh-Ming LiouUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium
Jan 11, 2017·The American Journal of Gastroenterology·William D CheySteven F Moss
Apr 8, 2017·Cleveland Clinic Journal of Medicine·Akiko ShiotaniDavid Y Graham
Aug 7, 2017·The Lancet. Gastroenterology & Hepatology·Yu-Ting KuoUNKNOWN Asian Pacific Alliance on Helicobacter and Microbiota

❮ Previous
Next ❯

Citations

Sep 6, 2019·Helicobacter·Anthony O'ConnorColm O'Morain
Nov 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Javier P Gisbert
Nov 3, 2020·Expert Opinion on Pharmacotherapy·Sotirios Georgopoulos, Vasilios Papastergiou
Jul 24, 2020·Minerva medica·Rocco M ZagariFranco Bazzoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.