Systematic review: non A-E, seronegative or indeterminate hepatitis; what is this deadly disease?

Alimentary Pharmacology & Therapeutics
P N BrennanK J Simpson

Abstract

A significant proportion of cases of acute liver failure (ALF) do not have an identifiable cause; so called "non A-E," "non A, non B, non C," "seronegative" or "indeterminate" hepatitis. However, this entity is clinically not well described. To collate the known incidence and outcomes in indeterminate hepatitis. This systematic review sought to identify potential aetiologies that ought to be considered, and identify likely future objectives in classification and treatment strategies for indeterminate hepatitis. Literature review to determine aetiological factors, prevalence and outcomes relating to indeterminate hepatitis. There is significant heterogeneity within the reported cases of indeterminate hepatitis in the literature. Some of the potential infective aetiologies which are reviewed here include: parvovirus B19 (PVB19), herpes simplex virus (HSV), Toga-Like Virus and the Annelloviridae (including SEN-V). Interestingly, this condition predominately affects middle aged women, with subacute progression of the liver failure. In addition, the prognosis of indeterminate hepatitis is poor, with reduced spontaneous survival compared with other causes of acute liver failure and increased need for emergency liver transplantation. ...Continue Reading

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Citations

Oct 16, 2018·Alimentary Pharmacology & Therapeutics·Keiichi FujiwaraNaoya Kato
May 31, 2019·Minerva gastroenterologica e dietologica·Barbara ImperatriceAlfredo Marzano
Oct 16, 2018·Alimentary Pharmacology & Therapeutics·Paul N BrennanKenneth J Simpson
Apr 6, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Hong ZhaoYi-Hua Zhou
Aug 15, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Su LinRajiv Jalan
Dec 23, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Su LinRajiv Jalan

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