Systematic review of anticoagulant treatment of catheter-related thrombosis

Thrombosis Research
Lisa Baumann KreuzigerWendy Lim

Abstract

Central venous catheter-related thrombosis (CRT) is a complication seen in patients requiring long-term intravenous access. Treatment of CRT is not standardized and international guidelines for treatment are based on extrapolation of evidence from lower extremity thrombosis. We performed a systematic review of the literature to evaluate if duration of anticoagulation affects the risk of recurrent venous thrombosis, post-thrombotic syndrome, or major hemorrhage. We searched PubMed, Embase, Medline, CINAHL, Cochrane, and ACP Journal club for studies of CRT treated with anticoagulation. Of 1648 titles and abstracts, 23 studies met our inclusion criteria. No randomized trials were identified. Duration of anticoagulation varied from 8 days to more than 6 months. Outcomes of patients with upper extremity thrombosis due to CRT or other etiologies were often combined. The incidence of post-thrombotic syndrome varied between 0 and 75% depending on the definition used. Seven percent of patients with upper extremity thrombosis treated with anticoagulation experienced recurrent deep vein thrombosis and 2.8% experienced pulmonary embolism. Major hemorrhage was reported in 2.8-4.9% of anticoagulated patients. Prospective studies evaluating t...Continue Reading

References

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Citations

Nov 26, 2015·Thrombosis Research·Aurélien Delluc, Marc Carrier
Jun 19, 2016·Der Anaesthesist·T KerzR Moringlane
Jun 2, 2018·The Cochrane Database of Systematic Reviews·Lara A KahaleElie A Akl
Nov 28, 2018·Blood·Noémie Kraaijpoel, Marc Carrier
Feb 2, 2019·Phlebology·Rafael Cires-DrouetBrajesh K Lal
Jun 3, 2020·The Journal of Vascular Access·Mitsutoshi ShindoYoshiyuki Morishita
Oct 31, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martin Garcia-NicolettiFrancis Calder
Dec 19, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Stavros K KakkosMelina Vega de Ceniga
Oct 20, 2019·The Journal of Emergency Medicine·Brit Long, Alex Koyfman

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