Systematic review of antimicrobial treatments for diabetic foot ulcers

Diabetic Medicine : a Journal of the British Diabetic Association
E A NelsonDASIDU Steering Group

Abstract

Foot ulcers in diabetes are associated with increased mortality, illness and reduced quality of life. Ulcer infection impairs healing and antimicrobial interventions may cure infection, aid healing and reduce amputation rates. To systematically review the evidence for antimicrobial interventions for foot ulcers in diabetes. We searched 16 databases, 11 Internet sites, three books, conference proceedings, a journal and bibliographies in November 2002. We included randomized controlled trials (RCTs) or controlled clinical trials (CCTs). Twenty-three studies investigated the effectiveness or cost-effectiveness of antimicrobial agents: intravenous antibiotics (n = 8); oral antibiotics (n = 5); topical antimicrobials (n = 4); subcutaneous granulocyte-colony stimulating factor (G-CSF) (n = 4); Ayurvedic preparations (n = 1): and sugar vs. antibiotics vs. standard care (n = 1). The trials were small and too dissimilar to be pooled. There is no strong evidence for any particular antimicrobial agent for the prevention of amputation, resolution of infection, or ulcer healing. Pexiganan cream may be as effective as oral ofloxacin for resolution of infection. Ampicillin and sulbactam cost less than imipenem/cilastatin, G-CSF cost less than...Continue Reading

References

Jan 1, 1992·The Australasian Journal of Dermatology·A R HalbertA Jopp-McKay
Oct 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·J A Hunt
Sep 1, 1989·The British Journal of Dermatology·B Gilchrist, C Reed
Aug 1, 1986·Journal of the American Academy of Dermatology·A AlinoviM Pini
Jan 1, 1984·Scandinavian Journal of Infectious Diseases·G ErikssonL O Kallings
Sep 1, 1980·Irish Journal of Medical Science·C H Walsh, C K Campbell
Feb 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·J ApelqvistJ Larsson
May 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M L GraysonA W Karchmer
Feb 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·E ChantelauC Metzger
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jul 1, 1996·Journal of the American Podiatric Medical Association·D G ArmstrongL B Harkless
Nov 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·E J BoykoD Davignon
Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P S McKinnonA W Karchmer
Oct 20, 1998·American Journal of Surgery·G E ReiberG W Gibbons
Dec 10, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·J MasonA Booth
Dec 15, 2000·Archives of Dermatology·D J MargolisJ A Berlin
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B BuemannA Astrup
Nov 13, 2001·Diabetes, Obesity & Metabolism·A YönemA Corakçi
Feb 28, 2002·Lancet·Kenneth F Schulz, David A Grimes
May 2, 2003·Medizinische Klinik·Andreas AmbroschRalf Lobmann
Dec 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A LipskyUNKNOWN Linezolid Diabetic Foot Infections Study Group
Nov 2, 1993·Journal of Wound Care·M H E Hermans, L L Bolton

❮ Previous
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Citations

Nov 23, 2006·Current Diabetes Reports·Stephen C DavisRobert Kirsner
Dec 21, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Haris M Rathur, Andrew J M Boulton
Nov 8, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A LipskyMichael Zasloff
Jun 3, 2011·Diabetes Technology & Therapeutics·David G Armstrong
Dec 10, 2009·Vascular Health and Risk Management·Michael Edmonds
May 4, 2011·World Journal of Diabetes·Jean-Louis RichardJean-Philippe Lavigne
Jan 1, 2012·Scientifica·Bauer E Sumpio
Apr 3, 2014·Diabetes Technology & Therapeutics·Constantijn E V B HazenbergSicco A Bus
May 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A Lipsky Infectious Diseases Society of America
Oct 26, 2014·BMC Surgery·Elroy P Weledji, Pius Fokam
Feb 3, 2007·Expert Review of Anti-infective Therapy·Philippa C MatthewsBenjamin A Lipsky
Jun 13, 2009·Expert Opinion on Drug Delivery·Catherine D GriffisDavid G Armstrong
Sep 3, 2013·The Medical Clinics of North America·Edgar J G Peters, Benjamin A Lipsky
May 16, 2014·Canadian Journal of Diabetes·UNKNOWN Canadian Diabetes Association Clinical Practice Guidelines Expert CommitteeJohn M Embil
Oct 16, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ilker UçkayBenjamin A Lipsky
May 18, 2010·Journal of the American Academy of Dermatology·Marissa J CarterRobert A Warriner
Sep 29, 2009·Physical Medicine and Rehabilitation Clinics of North America·Andy O Miller, Michael Henry
Feb 23, 2008·Diabetes Research and Clinical Practice·Konstantinos Z VardakasMatthew E Falagas
Feb 5, 2008·Diabetes & Metabolism·A Hartemann-Heurtier, E Senneville
Dec 25, 2007·International Journal of Antimicrobial Agents·Nesrene S OmarJim Gray
Jul 14, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yeu-Chun KimMark R Prausnitz
Nov 19, 2010·Journal of Clinical Nursing·Kimberly W Simms, Kathleen Ennen
Jun 13, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·João J MendesMiguel Garcia
Jun 8, 2013·Dermatologic Therapy·Nicholas A RichmondAlejandra C Vivas
Aug 6, 2013·Diabetes, Obesity & Metabolism·I UçkayB A Lipsky
Mar 5, 2015·Expert Opinion on Pharmacotherapy·Mohamed AbbasBenjamin A Lipsky
Sep 1, 2012·European Journal of Microbiology & Immunology·Z M H KheirallaE El-Sayed Moustafa
Oct 17, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N SaltogluM Sert
Mar 16, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B A Lipsky
May 21, 2010·The International Journal of Lower Extremity Wounds·Aonghus O'LoughlinTimothy O'Brien
Aug 6, 2010·Foot & Ankle Specialist·Christy L ScimecaDavid G Armstrong
Jun 27, 2013·The Cochrane Database of Systematic Reviews·Jo C DumvilleKatharine Speak
Jul 13, 2013·The Cochrane Database of Systematic Reviews·Jo C DumvilleKatharine Speak
Aug 8, 2013·The Cochrane Database of Systematic Reviews·Jo C DumvilleKatharine Speak
Sep 5, 2015·The Cochrane Database of Systematic Reviews·Anna Selva OlidBenjamin A Lipsky
Jul 15, 2015·The Cochrane Database of Systematic Reviews·Lihua WuSally Em Bell-Syer
Jun 7, 2013·The Cochrane Database of Systematic Reviews·Jo C DumvilleKatharine Speak
Apr 9, 2008·Diabetes/metabolism Research and Reviews·Benjamin A Lipsky
Apr 20, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·W J Jeffcoate
Oct 23, 2012·Hospital Practice·Andrea D MaderalRobert S Kirsner
Aug 21, 2013·The Cochrane Database of Systematic Reviews·Mario CrucianiFausto de Lalla
Oct 25, 2008·Journal of Wound Care·R White, C McIntosh
Mar 10, 2015·Expert Review of Anti-infective Therapy·Raffaele SerraStefano de Franciscis
Aug 25, 2016·Plastic and Reconstructive Surgery·Michelle GompelmanEdgar J G Peters

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