PMID: 15332420Aug 31, 2004Paper

Systematic review of bisphosphonates for hypercalcaemia of malignancy

Palliative Medicine
Y SaundersSteering Group

Abstract

Bisphosphonates are the treatment of choice for hypercalcaemia of malignancy (HCM) but there is no consensus regarding which drug or dose should be given. We designed a systematic review to investigate the efficacy of bisphosphonates in the treatment of HCM. We identified randomized controlled trials (RCTs) by searching electronic databases, scanning of reference lists, and consultation with experts and pharmaceutical companies. Foreign papers were translated. Inclusion criteria were RCTs, confirmed malignant disease and measurement of serum calcium (ionized or corrected for albumin) postrehydration. The primary outcome was number of patients achieving normocalcaemia. Secondary outcomes were time to normocalcaemia, time to relapse and toxicity. Twenty-seven papers and two abstracts, using intravenous bisphosphonates, fulfilled the inclusion criteria. Data from 26 studies were used in analyses. Due to the heterogeneity of studies, meta-analysis could not be performed. Pamidronate was more effective than placebo, mithramycin, etidronate (7.5 mg/kg) and low-dose clodronate (600 mg), but equal to higher dose clodronate (1500 mg). Clodronate and etidronate were superior to placebo; incadronate was superior to elcatonin; gallium nitr...Continue Reading

References

Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S RotsteinS Strid
Sep 1, 1992·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B ThürlimannD Thiébaud
Mar 12, 1992·International Journal of Cancer. Journal International Du Cancer·R RizzoliJ P Bonjour
Apr 30, 1992·The New England Journal of Medicine·J P Bilezikian
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R GucalpR Siegel
Aug 11, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R P WarrellG Heller
Jan 1, 1990·Calcified Tissue International·L A Wisneski
May 19, 1990·BMJ : British Medical Journal·M HarrisonJ Waxman
Dec 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J J BodyA Borkowski
May 1, 1987·Archives of Internal Medicine·R S WitteT P Jacobs
Oct 1, 1986·European Journal of Clinical Investigation·C HaslingL Mosekilde
Mar 9, 1985·British Medical Journal·J A Kanis, A J Yates
Dec 15, 1973·British Medical Journal·R B PayneJ R Milner
Mar 1, 1983·The American Journal of Medicine·E S SirisR E Canfield
Mar 1, 1983·The American Journal of Medicine·G R MundyD A Heath
Jun 23, 1983·The New England Journal of Medicine·A JungM E Kitler
May 1, 1980·The Journal of Clinical Investigation·M C ChapuyE P Vignon
Jan 1, 1983·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·O Siggaard-AndersenN Fogh-Andersen
Nov 12, 1994·BMJ : British Medical Journal·K DickersinC Lefebvre
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S R NussbaumB J Gertz
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M PecherstorferD Thiébaud
May 1, 1996·The Annals of Pharmacotherapy·M A ChisholmA T Taylor
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J VinholesR E Coleman
Jan 1, 1997·British Journal of Cancer·S H RalstonJ J Body
Aug 1, 1997·Calcified Tissue International·M E MartínezM T Del Campo
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R BerensonR D Knight
Mar 12, 1998·Endocrine Reviews·H Fleisch
Apr 29, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S P LuckmanM J Rogers
Sep 19, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V GrillT J Martin
Sep 25, 1998·Journal of Internal Medicine·B KristensenH Loft

❮ Previous
Next ❯

Citations

May 23, 2006·Clinical & Experimental Metastasis·S H Tannehill-GreggT J Rosol
Jul 19, 2005·Journal of Mammary Gland Biology and Neoplasia·Samantha DeMauro, John Wysolmerski
Mar 22, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·David R P Guay
Jun 15, 2006·Mayo Clinic Proceedings·Thorvardur R HalfdanarsonTimothy J Moynihan
Aug 8, 2007·Clinical Lung Cancer·Charles J DiskinThomas B Carter
May 22, 2007·Hematology/oncology Clinics of North America·Rachel LaymanCatherine Van Poznak
Dec 25, 2009·European Journal of Cancer Care·S SamphaoO Eremin
Jun 10, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kosuke KusamoriAkira Yamamoto
Jun 28, 2005·Critical Reviews in Oncology/hematology·Giovanni Selvaggi, Giorgio V Scagliotti
Jul 23, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Akira ShimadaTatsuya Morita
Oct 17, 2013·Journal of Intensive Care Medicine·Joshua D Maier, Steven N Levine
Jul 23, 2009·The Annals of Pharmacotherapy·Jonathan McMahan, Travis Linneman
Nov 26, 2009·Current Opinion in Obstetrics & Gynecology·Richard L Theriault
Oct 21, 2006·The Cochrane Database of Systematic Reviews·K K YuenM D Mason
Nov 26, 2013·International Journal of Palliative Nursing·Annie Pettifer, Sarah Grant
Dec 27, 2017·The Cochrane Database of Systematic Reviews·Sascha MachereyNicole Skoetz
Jan 23, 2020·AACE Clinical Case Reports·Roselyn Cristelle Isidro MateoHarold Noah Rosen
Aug 3, 2021·Curēus·Edwin McCrayChristopher Stewart

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.