Systematic review of clinical data with BNO-101 (Sinupret) in the treatment of sinusitis

Forschende Komplementärmedizin = Research in Complementary Medicine
Jörg MelzerReto Brignoli

Abstract

The herbal formula BNO-101 (containing Gentianae radix, Primulae flos, Rumicis herba, Sambuci flos and Verbenae herba; ratio 1:3:3:3:3) has been widely employed as a 'mucoactive' agent in Germany for 70 years for the symptoms of respiratory infections. This paper reviews the clinical evidence of BNO-101 in sinusitis. The systematic search identified 22 studies with BNO-101. Out of these, 6 controlled trials on sinusitis were reassessed according to predefined criteria. 4 trials had almost identical designs and could be examined by meta-analysis. The database comprised approximately 900 patients, mostly young adult males. After 2 weeks of treatment, verum was significantly superior to placebo (2 RCTs, 159 vs. 160 patients, both add-on to antibacterial treatment). The benefit regards the patients' assessment ('cured': verum = 61.1%, placebo = 34.5%), reduction of drain obstruction, headache and radiological signs (all p < 0.05). Comparing BNO-101 to ambroxol (2 RCTs, 151 vs. 150 patients, add-on to antibacterials in 13% of the cases) the patients' assessment after 2 weeks showed no difference, although it favoured BNO-101 in chronic cases ('cured' BNO-101 = 37.1%, ambroxol = 12.5%; p < 0.05). It also favoured BNO-101 concerning p...Continue Reading

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Citations

Sep 17, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Raphael Richard Ciuman
Mar 13, 2012·Fitoterapia·Antonietta RossiOliver Werz
Dec 17, 2014·Acta Oto-laryngologica·Rainer JundClaus Bachert
Jan 18, 2017·MMW Fortschritte der Medizin·Nina Dippold, Ludger Klimek
Dec 5, 2016·European Annals of Otorhinolaryngology, Head and Neck Diseases·O LaccourreyeP Bonfils
Feb 16, 2017·Phytotherapy Research : PTR·Randall S Porter, Robert F Bode
Feb 9, 2013·Postgraduate Medicine·M Jennifer Derebery, Peter V Dicpinigaitis
Sep 13, 2007·Forschende Komplementärmedizin = Research in Complementary Medicine·Elke JeschkeHarald Matthes
May 28, 2015·MMW Fortschritte der Medizin·Rainer JundClaus Bachert

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