Systematic review of health-related quality of life and patient-reported outcome measures in gestational trophoblastic disease: a parallel synthesis approach

The Lancet Oncology
Jane IresonJohn A Tidy

Abstract

Gestational trophoblastic disease is a rare complication of pregnancy that can develop into cancer. Medical outcomes of gestational trophoblastic disease are well researched, but the effect of the disease on health-related quality of life (HRQOL) requires attention if care is to be improved. This systematic review was designed to establish the effect of gestational trophoblastic disease and its treatment on HRQOL and to identify the appropriateness of HRQOL measures. Quantitative studies found HRQOL in long-term survivors of gestational trophoblastic disease to be at or above population norms. The disease had a negative effect on HRQOL for patients who experienced physical, psychological, and social sequelae related to the condition. Clinically significant levels of anxiety, depression, sexual dysfunction, and fertility-related distress were found in these patients. The results should be treated with caution because the evidence base was limited to small heterogeneous samples, data were retrospective, and a range of measures was used. Within qualitative studies on HRQOL for survivors of gestational trophoblastic disease, new conditions emerged, including nerve damage, fatigue, amenorrhoea, and grief. These areas are not capture...Continue Reading

Citations

Oct 1, 2020·BJOG : an International Journal of Obstetrics and Gynaecology
Nov 13, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Valentina Di MatteiMassimo Candiani
Jul 28, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·L J BlokP B Ottevanger
Jun 27, 2021·Current Opinion in Oncology·John CoulterChristianne Lok

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