Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials

Antioxidants
Gina NaumanChanning J Paller

Abstract

Ascorbate (vitamin C) has been evaluated as a potential treatment for cancer as an independent agent and in combination with standard chemotherapies. This review assesses the evidence for safety and clinical effectiveness of intravenous (IV) ascorbate in treating various types of cancer. Single arm and randomized Phase I/II trials were included in this review. The PubMed, MEDLINE, and Cochrane databases were searched. Results were screened by three of the authors (GN, RP, and CJP) to determine if they met inclusion criteria, and then summarized using a narrative approach. A total of 23 trials involving 385 patients met the inclusion criteria. Only one trial, in ovarian cancer, randomized patients to receive vitamin C or standard of care (chemotherapy). That trial reported an 8.75 month increase in progression-free survival (PFS) and an improved trend in overall survival (OS) in the vitamin C treated arm. Overall, vitamin C has been shown to be safe in nearly all patient populations, alone and in combination with chemotherapies. The promising results support the need for randomized placebo-controlled trials such as the ongoing placebo-controlled trials of vitamin C and chemotherapy in prostate cancer.

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E Cameron, L Pauling
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·E Cameron, L Pauling
Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·H LangemannC G Honegger
May 15, 1988·International Journal of Cancer. Journal International Du Cancer·C G HoneggerW Krenger
Oct 22, 1987·The New England Journal of Medicine·R D Mosteller
Jan 17, 1985·The New England Journal of Medicine·R E Wittes
Oct 1, 1974·Chemico-biological Interactions·E Cameron, L Pauling
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L Pauling
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·M LevineL R Cantilena
Jun 20, 2000·FEBS Letters·F Antunes, E Cadenas
Aug 30, 2000·Journal of the American College of Nutrition·S J Padayatty, M Levine
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·M LevineJ Morrow
Apr 8, 2004·Annals of Internal Medicine·Sebastian J PadayattyMark Levine
Nov 25, 2004·The Journal of Biological Chemistry·Iman M AhmadDouglas R Spitz
Sep 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Qi ChenMark Levine
Mar 29, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sebastian J PadayattyMark Levine
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James R BerensonHoward S Yeh
May 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Qi ChenMark Levine
Jun 12, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L J HofferW H Miller
Aug 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Qi ChenMark Levine
Mar 16, 2011·Free Radical Biology & Medicine·Michael Graham EspeyQi Chen
Jun 26, 2012·Biochimica Et Biophysica Acta·Juan DuGarry R Buettner
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Georgina N Masoud, Wei Li
Jan 16, 2016·Cell Research·Jiska van der Reest, Eyal Gottlieb

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Citations

Jul 31, 2019·Antioxidants·Andrijana Meščić MacanSilvana Raić-Malić
May 15, 2020·Critical Care Medicine·Fumitaka YanaseRinaldo Bellomo
Apr 11, 2019·Nature Reviews. Cancer·Bryan NgoJihye Yun
Aug 6, 2019·Frontiers in Cell and Developmental Biology·Taylor Lee ChongLuisa Cimmino
Mar 21, 2020·Frontiers in Pharmacology·Francisco J RoaCarola Muñoz-Montesino
Jan 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wiktoria BlaszczakBłażej Rubiś
Apr 3, 2019·Nutrients·Harri Hemilä, Elizabeth Chalker
Mar 21, 2019·The Analyst·Taiki MiyazawaYuji Miyahara
Aug 6, 2020·International Journal of Molecular Sciences·Michał CiebieraAyman Al-Hendy
May 16, 2020·Oxidative Medicine and Cellular Longevity·Rumiana BakalovaTatsuya Higashi
Aug 9, 2019·Molecular Human Reproduction·Changyin ZhouBo Xiong
Jan 8, 2019·Redox Biology·Upadhyayula Sai SrinivasAnand D Jeyasekharan
Jan 27, 2021·Free Radical Biology & Medicine·Sheetal PandayMahendra Kavdia
Oct 30, 2020·Journal of Experimental & Clinical Cancer Research : CR·Walaa DarwicheHussein Ghamlouch
Jan 21, 2021·International Journal of Environmental Research and Public Health·Kaja MichalczykAneta Cymbaluk-Płoska
Feb 6, 2021·Journal of Neurotrauma·Lauren KangisserMark P Plummer
Mar 7, 2021·Nutrients·Martin Doseděl On Behalf Of The Oemonom
Jan 15, 2019·Redox Biology·Maret G TraberRichard S Bruno
Apr 11, 2021·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Ingrid O TravassosElisângela P de Silveira-Lacerda
Jul 1, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Richard BedlackPaul Wicks
Jul 14, 2021·Antioxidants & Redox Signaling·Christophe Glorieux, Pedro Buc Calderon
Sep 21, 2021·Seminars in Respiratory and Critical Care Medicine·Ankita AgarwalJonathan E Sevransky

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Methods Mentioned

BETA
xenografts
surgical resection

Clinical Trials Mentioned

NCT03175341
NCT02516670
NCT01852890
NCT01752491
NCT03410030
NCT02905578
NCT02344355

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