Systematic review of ketogenic diet use in adult patients with status epilepticus

Epilepsia Open
Sherif Hanafy MahmoudJessica Buhler

Abstract

Status epilepticus (SE) is a medical emergency that is associated with a significant morbidity and mortality. Recently, there has been significant interest in the use of ketogenic diets (KD) in the management of SE. KD is a high-fat, low-carbohydrate, and adequate protein diet that has been shown to be a safe and effective adjuvant to present SE management in patients with refractory epilepsy. Many case reports and case series have demonstrated the potential safety and effectiveness of KD for the acute treatment of SE; however, quality studies remain scarce on this topic. The purpose of this systematic review is to summarize the available evidence for the safety and effectiveness of KD in adults with SE. A literature search was performed in MEDLINE, EMBASE, Cochrane Library, and CINAHL (September 14, 2018). The search was repeated on March 27, 2019, to include any studies published since the original search. Keywords related to KD and SE were used. Studies were selected based on the reported use of the KD in SE. The search resulted in a total of 954 records. After screening and full-text review, 17 articles were included in this review: four observational studies, 10 case reports, and 3 case series. Based on the observational s...Continue Reading

References

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Citations

Oct 28, 2020·Antioxidants·Tsu-Kung LinYao-Chung Chuang
Mar 6, 2021·Current Opinion in Neurology·Andrea O Rossetti, Vincent Alvarez
Apr 6, 2021·Current Treatment Options in Neurology·Tachira TavarezLauren Koffman
Apr 27, 2021·Neurologic Clinics·Pouya Alexander AmeliCarolina B Maciel
Sep 30, 2021·Current Neurology and Neuroscience Reports·Sergio A Ramírez-SalazarJorge G Ortiz García
Sep 18, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Rowena FieldKieron Rooney

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