Systematic Review of Methods Used for the Microvascular Assessment of Peripheral Arterial Disease

Cardiovascular Drugs and Therapy
Qinzhong Chen, Robert S Rosenson

Abstract

Lower extremity peripheral arterial disease (LEAD) is increasing in prevalence in low with approximately 202 million people affected with LEAD worldwide. Certain subgroups of individuals (cigarette smokers, diabetics) that are particularly high risk for LEAD and major adverse limb events (MALE). Conventionally, the ankle-brachial index (ABI) is the recommended screening test for LEAD. However, the ABI has several limitations, particularly in patients with diabetes. These limitations include increased measurement variability with severity of LEAD, non-compressible calcified arteries inability to detect arterial disease distal to the ankle precludes assessment of disease in the foot where many ulcers can occur, and underestimation of the extent of microvascular occlusive disease. In this systematic review, we discuss methods used for the assessment of microvascular disease and compare outcomes that encompass microvascular flow with the ABI and toe-brachial index (TBI).

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Citations

Nov 5, 2020·International Journal of Molecular Sciences·Paolo SeverinoFrancesco Fedele
Mar 11, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·E Hope WeisslerW Schuyler Jones
Jul 6, 2021·Journal of Diabetes Science and Technology·Samuel JettCraig C Weinkauf

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