Systematic Review of Modern Case Series of Squamous Cell Cancer Arising in a Chronic Ulcer (Marjolin's Ulcer) of the Skin.

JCO Global Oncology
Mohamed A AbdiTimothy P Hanna

Abstract

Marjolin's ulcer is an aggressive cutaneous malignancy that arises in chronic nonhealing wounds. A review of modern series describing Marjolin's ulcer would be helpful in defining optimal management strategies and expected outcomes. A systematic review was performed on October 18, 2018, by querying Medline and EMBASE. Key inclusion criteria were as follows: human studies, English language, published in 2000 or later, > 10 patients, and at least 80% of the patients having squamous cell carcinoma (SCC) histology. There were 599 patients in 14 case series from 10 countries; 82% of patients were from low-income and middle-income countries, and 48% were women. Overall, 65% of the ulcers were preceded by burns. Mean latency ranged from 11 years to 41 years (median, 28 years). Lower extremities were the most common site (62%). Differentiation was reported as well differentiated (64%), moderately differentiated (27%), or poorly differentiated (9%). Almost one third of cases were clinically node positive, though only 7% of all cases (24 of 334) were confirmed to be pathologically involved. Distant metastasis rates were reported in only 7 series, with median rate of 5% (range, 0%-27%). The main treatment modality was surgical excision (7...Continue Reading

References

Nov 20, 2001·American Journal of Otolaryngology·M O Al-OthmanR J Amdur
Sep 24, 2004·International Journal of Radiation Oncology, Biology, Physics·Winkle KwanVeronika Moravan
May 18, 2005·Burns : Journal of the International Society for Burn Injuries·Eser AydoğduTayfun Aköz
Jul 31, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·P CombemaleUNKNOWN Angiodermatology Group, French Society of Dermatology
Jul 2, 2009·Plastic and Reconstructive Surgery·Eray Copcu
Feb 18, 2012·World Journal of Surgical Oncology·Phillipo L ChalyaJaphet M Gilyoma
Oct 22, 2013·Journal of Cutaneous Medicine and Surgery·Aysin Karasoy YesiladaHazim Orhan Kizilkaya
Dec 18, 2013·World Journal of Surgical Oncology·Nanze YuRu Zhao
Sep 1, 2011·The Journal of the American College of Certified Wound Specialists·Brian PekarekLawrence Osher
Feb 27, 2015·Burns : Journal of the International Society for Burn Injuries·Kishore Kumar DasSazzad Khandkar
Sep 27, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stefanie Reich-SchupkeMarkus Stücker
Dec 2, 2015·Experimental and Therapeutic Medicine·Rui ShenXiaodong Chen
Jul 26, 2017·The Kaohsiung Journal of Medical Sciences·Melike OruçUğur Koçer
Jun 5, 2018·The New England Journal of Medicine·Michael R MigdenMatthew G Fury

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Citations

Jun 9, 2021·Journal of Immunotherapy·Sophia Z ShalhoutDavid M Miller
Aug 14, 2021·Cell Metabolism·Sabine A EmingEdward J Pearce

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Methods Mentioned

BETA
biopsy
dissection
amputation

Software Mentioned

Ovid

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

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