Systematic Review of Pharmacologic Treatments of Pain After Spinal Cord Injury: An Update

Archives of Physical Medicine and Rehabilitation
Swati MehtaSpinal Cord Injury Rehabilitation Evidence Team

Abstract

To update a systematic review of published research on pharmacotherapy for pain post-spinal cord injury (SCI). PubMed/MEDLINE, CINAHL, Embase, and PsycINFO databases were searched for articles from 2009 to September 2015 examining treatment of pain post-SCI. Studies were included for analysis if they met the following 4 a priori criteria: (1) written in the English language; (2) ≥50% of subjects had an SCI, unless results were stratified by population type; (3) participants included ≥3 subjects with an SCI; and (4) any intervention involving pharmacologic treatment for the improvement of pain. Randomized controlled trials were assessed for methodologic quality using the Physiotherapy Evidence Database scoring system. All research designs were given a level of evidence according to a modified Sackett Scale. Seven new studies met our inclusion criteria. The new studies fell into the following categories: analgesics (n=1), anticonvulsants (n=2), antidepressants (n=2), antispastics (n=1), and cannabinoids (n=1). There was evidence for 5 new pharmacotherapies among the SCI population; these included the following: oxycodone, duloxetine, venlafaxine, phenol block, and dronabinol. Levels of evidence for all therapy modalities were upd...Continue Reading

References

Jan 1, 1991·Paraplegia·P G Loubser, W H Donovan
Oct 1, 1996·Journal of Pain and Symptom Management·P G Loubser, N M Akman
Mar 1, 2002·The Australian Journal of Physiotherapy·Anne M MoseleyChristopher G Maher
Mar 8, 2002·The Clinical Journal of Pain·John David PutzkeT J Ness
Mar 23, 2002·Stereotactic and Functional Neurosurgery·E I UhleH Bertalanffy
Apr 26, 2002·Pain·Nanna B FinnerupTroels S Jensen
May 31, 2002·Spinal Cord·T-P ToD J Brown
Mar 18, 2004·Acta Anaesthesiologica Scandinavica·A KvarnströmT Gordh
Dec 1, 2007·Archives of Physical Medicine and Rehabilitation·Diana H RintalaPaul G Loubser
Mar 22, 2008·American Journal of Physical Medicine & Rehabilitation·Christina MarciniakChristine Gagnon
Apr 1, 2009·The Clinical Journal of Pain·Cecilia Norrbrink, Thomas Lundeberg
Jun 10, 2009·Spinal Cord·N B FinnerupT S Jensen
Mar 26, 2010·BMJ : British Medical Journal·Toni TanUNKNOWN Guideline Development Group
May 4, 2010·Archives of Physical Medicine and Rehabilitation·Robert W TeasellUNKNOWN Spinal Cord Injury Rehabilitation Evidence Research Team
May 16, 2014·European Journal of Pain : EJP·S van GorpJ Patijn
Jul 6, 2014·Archives of Physical Medicine and Rehabilitation·Swati MehtaRobert W Teasell

❮ Previous
Next ❯

Citations

Apr 10, 2016·Journal of Neuroinflammation·Alessandra Cadete MartiniGiles Alexander Rae
May 30, 2017·Experimental Neurology·Andrew D GaudetLinda R Watkins
Feb 10, 2018·Spinal Cord Series and Cases·Sonia Vidal RodriguezFrancisco Serrano Saenz de Tejada
Aug 4, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Noelle E CarlozziAnna L Kratz
Mar 18, 2020·The Journal of Spinal Cord Medicine·Mendel Kupfer, Christopher S Formal
Nov 21, 2018·Disability and Rehabilitation·Nichole StettenAmy V Blue
Feb 6, 2020·BMC Complementary Medicine and Therapies·Nadia Montero-OleasDaniel Simancas-Racines
Jan 1, 2016·Expert Review of Ophthalmology·Anat GalorConstantine D Sarantopoulos
Dec 12, 2019·Systematic Reviews·Misty PrattBrian Hutton
Aug 15, 2020·Spinal Cord Series and Cases·T C CrulM W M Post
Aug 8, 2018·Spinal Cord Series and Cases·Thomas N Bryce
May 14, 2018·Journal of Acupuncture and Meridian Studies·Qianqian FanYun Xia
Apr 2, 2020·Anaesthesia Critical Care & Pain Medicine·A RoquillyH Quintard
Jan 12, 2021·Neurobiology of Pain·Courtney A BannermanNader Ghasemlou
Nov 24, 2020·Archives of Physical Medicine and Rehabilitation·Nicole D DiPiroJames S Krause
Apr 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sajad FakhriMasoumeh Jorjani
Apr 13, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Clare CanavanBrona M Fullen
Oct 7, 2021·The Journal of Spinal Cord Medicine·Jeanne M ZancaTrevor A Dyson-Hudson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Botulism

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.