Systematic review of the benefits and risks of neoadjuvant chemoradiation for oesophageal cancer

The British Journal of Surgery
E F W Courrech StaalJohanna W van Sandick

Abstract

Surgery alone for locally advanced oesophageal cancer is associated with low cure rates. The benefits and risks of neoadjuvant chemoradiation for patients with oesophageal cancer were evaluated. A systematic review of publications between 2000 and 2008 on neoadjuvant chemoradiation for oesophageal cancer was undertaken. Thirty-eight papers comprising 3640 patients met the inclusion criteria. Chemoradiation regimens varied widely with a predominance of 5-fluorouracil/cisplatin chemotherapy. Chemoradiation-related toxicity was reported in only ten studies and consisted mainly of neutropenia. The chemoradiation-related mortality rate was 2.3 per cent. The mean R0 resection rate and pathological complete response (pCR) rate were 88.4 and 25.8 per cent respectively. Postoperative morbidity was not uniformly reported. The in-hospital mortality rate after oesophagectomy following chemoradiation was 5.2 per cent. Five-year survival rates varied from 16 to 59 per cent in all patients and from 34 to 62 per cent in those with a pCR. Chemoradiation had a temporary negative effect on quality of life. Neoadjuvant chemoradiation regimens for oesophageal cancer vary widely. Besides traditional outcome variables (such as survival), other parame...Continue Reading

References

Nov 1, 1993·The British Journal of Surgery·P M SagarP Quirke
Aug 15, 1996·The New England Journal of Medicine·T N WalshT P Hennessy
Oct 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M BlazebyJ R Farndon
Dec 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I F Tannock
Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·K JunkerK M Müller
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S G UrbaM Strawderman
Mar 22, 2001·The British Journal of Surgery·J I GehR Glynne-Jones
Apr 24, 2001·International Journal of Radiation Oncology, Biology, Physics·J H KimY I Min
Jan 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C Hennequin, V Favaudon
Nov 22, 2002·The New England Journal of Medicine·Jan B F HulscherJ Jan B van Lanschot
Jun 27, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M BlazebyUNKNOWN European Organisation for Research and Treatement of Cancer Gastrointestinal and Quality of Life Groups
Aug 5, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·O HagryT Lerut
Sep 23, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jessica S DoningtonPeter C Pairolero
Jan 7, 2004·American Journal of Surgery·Andreas ImdahlGünther Ruf
Mar 17, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Scott T KelleyRichard C Karl
Mar 19, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E D MulliganJ V Reynolds
Sep 28, 2004·BMC Medicine·Richard A MalthanerUNKNOWN Members of the Gastrointestinal Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care
Oct 23, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B L D M BrücherJ R Siewert
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Zhongxing LiaoRitsuko Komaki
Jan 28, 2005·Surgery·Sarah E GreerJohn D Birkmeyer
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Mar 23, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam C BergerMelvyn Goldberg
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael StahlHansjochen Wilke
Jun 4, 2005·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K BujkoUNKNOWN Polish Colorectal Study Group
Aug 2, 2005·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X ZhangP G Devitt
Sep 1, 2005·The Lancet Oncology·Bryan H BurmeisterUNKNOWN Australasian Gastro-Intestinal Trials Group
Oct 8, 2005·Surgical Endoscopy·X ZhangJ R Bessell
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rajyalakshmi LuthraJaffer A Ajani

❮ Previous
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Citations

Apr 14, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Donald E Low
Jan 16, 2014·Indian Journal of Surgical Oncology·Keduovinuo K KeditsuC S Pramesh
Nov 23, 2013·Journal of Cardiothoracic Surgery·Mael Chalret du RieuNicolas Carrère
Sep 10, 2014·International Journal of Radiation Oncology, Biology, Physics·Sil KordesJohanna W Wilmink
Jan 18, 2013·Digestive Diseases and Sciences·Sajneet K Khangura, Bruce D Greenwald
Aug 21, 2013·Acta Oncologica·Mette WintherMarianne Nordsmark
Nov 10, 2013·Thoracic Surgery Clinics·B Mark Smithers, Iain Thomson
Sep 17, 2013·Seminars in Roentgenology·Kyung Eun ShinYoung Mog Shim
Mar 16, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·S GwynneT Crosby
Jul 31, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J StiekemaJ W van Sandick
Aug 14, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Frederic Di FiorePierre Michel
Aug 28, 2012·Seminars in Thoracic and Cardiovascular Surgery·Linda W Martin
May 2, 2012·Experimental and Molecular Pathology·Ryan TrowbridgeDevendra K Agrawal
Oct 18, 2011·International Journal of Radiation Oncology, Biology, Physics·Brian M AlexanderNoah C Choi
Oct 4, 2011·The Annals of Thoracic Surgery·Jae Y KimWayne L Hofstetter
Jun 21, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·M HingoraniR Roy
Jul 17, 2015·Digestive Diseases and Sciences·Ines GockelHauke Lang
Jul 15, 2015·World Journal of Surgery·Esther W de Bekker-GrobBas P L Wijnhoven
Nov 7, 2012·British Journal of Pharmacology·S J FordC Tselepis
Sep 29, 2011·Annals of the New York Academy of Sciences·William S TwaddellStephen J Sontag
Mar 31, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J M BowenD M K Keefe
Sep 19, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T C FangK S Dua
May 16, 2015·Journal of Pain and Symptom Management·Andrea L ChevilleMatthew M Clark
Jun 21, 2011·The Lancet Oncology·Katrin M SjoquistUNKNOWN Australasian Gastro-Intestinal Trials Group
Jul 31, 2014·International Journal of Clinical Oncology·Kazuki IshikawaYasumasa Nishimura
Mar 15, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Mathieu GauthéUNKNOWN Fédération Francophone de Cancérologie Digestive (FFCD)
Feb 15, 2015·International Journal of Radiation Oncology, Biology, Physics·Dok Hyun YoonSung-Bae Kim
Jun 21, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·S GwynneA Bateman

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