Systematic review of the effect of dopamine receptor agonists on patient health-related quality of life

Parkinsonism & Related Disorders
Pablo Martinez-Martin, Mónica M Kurtis

Abstract

Dopamine receptor agonists have demonstrated effectiveness in managing Parkinson's disease both as monotherapy and as adjunctive treatment to L-dopa. Dopamine receptor agonist therapy may reduce the risk of developing motor complications; however, it can also produce undesirable side-effects. Patient health-related quality of life (HRQoL) is a comprehensive outcome that may be useful in evaluating these complex effects. This is a systematic review of the reported clinical trials that have investigated the effect of dopamine receptor agonists on HRQoL. A literature search was carried out using Medline, cut-off date 30 June 2009. Identified manuscripts were classified according to level of evidence; Level I studies were rated for quality; relative change (RC) and effect size (ES) were calculated when possible; and dopamine receptor agonist efficacy in improving HRQoL was assigned accordingly. Overall, 18 manuscripts reporting clinical trial outcomes on seven dopamine receptor agonists were reviewed. Six studies were randomized and double-blinded; five were controlled with placebo; and 10 were comparative. Sample sizes ranged from 4 to 506 patients (mean, 181.1 +/- 143.7), and follow-up ranged from 1.5 to 48 months (11.8 +/- 14.2)...Continue Reading

References

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Citations

Jun 26, 2012·Current Heart Failure Reports·Denise Hilfiker-KleinerKaren Sliwa
Nov 22, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Miguel Ángel García-GordilloJosé María Abellán-Perpiñán
Jul 8, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Pablo Martinez-MartinAnette Schrag
Jul 5, 2011·Expert Review of Neurotherapeutics·Santiago Perez-LloretOlivier Rascol
Jul 5, 2011·Neurología : publicación oficial de la Sociedad Española de Neurología·A Alonso CánovasJ C Martínez Castrillo
Mar 22, 2012·Therapeutic Advances in Neurological Disorders·Pablo Martinez-Martin, Mónica M Kurtis
Jan 1, 2011·Journal of Central Nervous System Disease·Paul S Fishman
May 15, 2015·CNS Drugs·Pablo Martinez-MartinMonica M Kurtis
Nov 4, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N V Titova

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