Systematic review of the indirect effect of pneumococcal conjugate vaccine dosing schedules on pneumococcal disease and colonization

The Pediatric Infectious Disease Journal
Jennifer D LooCynthia G Whitney

Abstract

To aid decision making for pneumococcal conjugate vaccine (PCV) use in infant national immunization programs, we summarized the indirect effects of PCV on clinical outcomes among nontargeted age groups. We systematically reviewed the English literature on infant PCV dosing schedules published from 1994 to 2010 (with ad hoc addition of 2011 articles) for outcomes on children >5 years of age and adults including vaccine-type nasopharyngeal carriage (VT-NP), vaccine-type invasive pneumococcal disease (VT-IPD) and syndromic pneumonia. Of 12,980 citations reviewed, we identified 21 VT-IPD, 6 VT-NP and 9 pneumonia studies. Of these 36, 21 (58%) included 3 primary doses plus PCV or pneumococcal polysaccharide vaccine (PPV23) booster schedule (3+1 or 3+PPV23), 5 (14%) 3+0, 9 (25%) 2+1 and 1 (3%) 2+0. Most (95%) were PCV7 studies. Among observational VT-IPD studies, all schedules (2+1, 3+0 and 3+1) demonstrated reductions in incidence among young adult groups. Among syndromic pneumonia observational studies (2+1, 3+0 and 3+1), only 3+1 schedules showed significant indirect impact. Of 2 VT-NP controlled trials (3+0 and 3+1) and 3 VT-NP observational studies (2+1, 3+1 and 3+PPV23), 3+1 and 3+PPV23 schedules showed significant indirect eff...Continue Reading

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Dec 18, 2013·The Pediatric Infectious Disease Journal·Jennifer D LooCynthia G Whitney

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Citations

Dec 18, 2013·The Pediatric Infectious Disease Journal·Jennifer D LooCynthia G Whitney
Dec 18, 2013·The Pediatric Infectious Disease Journal·Katherine E Fleming-DutraKatherine L O'Brien
Dec 18, 2013·The Pediatric Infectious Disease Journal·Jennifer D LooCynthia G Whitney
Aug 28, 2015·The Journal of Infectious Diseases·Sundia Cassandra PingaliDaniel M Weinberger
Feb 26, 2016·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Alexander Kuhlmann, J-Matthias Graf von der Schulenburg
Nov 5, 2015·Human Vaccines & Immunotherapeutics·Kristin Moffitt, Richard Malley
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Jan 16, 2021·Human Vaccines & Immunotherapeutics·Kubra AykacMehmet Ceyhan
Aug 12, 2021·Expert Review of Vaccines·Claire von MollendorfFiona M Russell
Jul 3, 2021·Pediatrics in Review·Liset Olarte, Mary Anne Jackson

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