Systematic review of the potential role of cannabinoids as antiproliferative agents for urological cancers

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada
Shreyas GandhiAnil Kapoor

Abstract

The palliative effects of cannabis sativa (marijuana), which include appetite stimulation, attenuation of nausea and emesis, and pain relief, are well known. The active components of cannabis sativa (cannabinoids) and their derivatives have received growing interest due to their diverse pharmacological activities, such as cell growth inhibition and tumour regression. The aim of this review is to look at the current evidence on the antiproliferative effects of cannabinoids in urological malignancies, including renal, prostate, bladder, and testicular cancers. We conducted a systematic review of studies exploring the effect of cannabinoids on tumour activity, including all study types except expert opinions. A formal search was run on Medline database from 1946 to September 2016, along with a hand-search on PubMed for relevant studies. The search yielded a total of 93 studies from Medline and PubMed, of which 23 studies were included in the final analysis. To date, there are various in vitro studies elucidating the potential mechanism of action of cannabinoids for urological cancers, along with population-based studies specifically for testicular malignancies. To date, no clinical trials have been conducted for urological cancer ...Continue Reading

Citations

Nov 28, 2019·JAMA Network Open·Mehrnaz GhasemiesfeDeborah Korenstein
Jan 26, 2020·International Journal of Molecular Sciences·Chiara LaezzaMaurizio Bifulco
Aug 26, 2020·International Journal of Molecular Sciences·Ava BachariNitin Mantri
Sep 3, 2020·International Journal of Molecular Sciences·Kanika SinghNitin Mantri
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Recardia SchoemanCarminita Frost

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